Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 908493, 9 pages
http://dx.doi.org/10.1155/2015/908493
Research Article

Oleuropein-Enriched Olive Leaf Extract Affects Calcium Dynamics and Impairs Viability of Malignant Mesothelioma Cells

1Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova, Italy
2Dipartimento di Scienze e Innovazione Tecnologica (DISIT), Università del Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy
3Dipartimento di Scienze della Terra dell’Ambiente e della Vita (DISTAV), Università degli Studi di Genova, Corso Europa 26, 16132 Genova, Italy

Received 14 September 2015; Revised 3 November 2015; Accepted 11 November 2015

Academic Editor: I-Min Liu

Copyright © 2015 Carla Marchetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Volta, E. Ranzato, S. Martinotti et al., “Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma,” PLoS ONE, vol. 8, no. 3, Article ID e58051, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. C. M. Diez, I. Trujillo, N. Martinez-Urdiroz et al., “Olive domestication and diversification in the Mediterranean basin,” The New Phytologist, vol. 206, no. 1, pp. 436–447, 2015. View at Publisher · View at Google Scholar
  3. C. Alarcón de la Lastra, M. D. Barranco, V. Motilva, and J. M. Herrerías, “Mediterranean diet and health: biological importance of olive oil,” Current Pharmaceutical Design, vol. 7, no. 10, pp. 933–950, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. S. N. El and S. Karakaya, “Olive tree (Olea europaea) leaves: potential beneficial effects on human health,” Nutrition Reviews, vol. 67, no. 11, pp. 632–638, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Delgado-Pertíñez, A. Chesson, G. J. Provan, A. Garrido, and A. Gómez-Cabrera, “Effect of different drying systems for the conservation of olive leaves on their nutritive value for ruminants,” Animal Research, vol. 47, no. 2, pp. 141–150, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Garcia-Maraver, D. Salvachúa, M. J. Martínez, L. F. Diaz, and M. Zamorano, “Analysis of the relation between the cellulose, hemicellulose and lignin content and the thermal behavior of residual biomass from olive trees,” Waste Management, vol. 33, no. 11, pp. 2245–2249, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Savournin, B. Baghdikian, R. Elias, F. Dargouth-Kesraoui, K. Boukef, and G. Balansard, “Rapid high-performance liquid chromatography analysis for the quantitative determination of oleuropein in Olea europaea leaves,” Journal of Agricultural and Food Chemistry, vol. 49, no. 2, pp. 618–621, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Ansari, M. Kazemipour, and S. Fathi, “Development of a simple green extraction procedure and HPLC method for determination of oleuropein in olive leaf extract applied to a multi-source comparative study,” Journal of the Iranian Chemical Society, vol. 8, no. 1, pp. 38–47, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Ryan, M. Antolovich, P. Prenzler, K. Robards, and S. Lavee, “Biotransformations of phenolic compounds in Olea europaea L.,” Scientia Horticulturae, vol. 92, no. 2, pp. 147–176, 2002. View at Publisher · View at Google Scholar
  10. S. H. Omar, “Oleuropein in olive and its pharmacological effects,” Scientia Pharmaceutica, vol. 78, no. 2, pp. 133–154, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Bulotta, M. Celano, S. M. Lepore, T. Montalcini, A. Pujia, and D. Russo, “Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases,” Journal of Translational Medicine, vol. 12, article 219, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Durlu-Özkaya and M. T. Özkaya, “Oleuropein using as an additive for feed and products used for humans,” Journal of Food Processing & Technology, vol. 2, no. 3, article 113, 2011. View at Publisher · View at Google Scholar
  13. B. Barbaro, G. Toietta, R. Maggio et al., “Effects of the olive-derived polyphenol oleuropein on human health,” International Journal of Molecular Sciences, vol. 15, no. 10, pp. 18508–18524, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Granados-Principal, J. L. Quiles, C. L. Ramirez-Tortosa, P. Sanchez-Rovira, and M. C. Ramirez-Tortosa, “Hydroxytyrosol: from laboratory investigations to future clinical trials,” Nutrition Reviews, vol. 68, no. 4, pp. 191–206, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Bernini, N. Merendino, A. Romani, and F. Velotti, “Naturally occurring hydroxytyrosol: synthesis and anticancer potential,” Current Medicinal Chemistry, vol. 20, no. 5, pp. 655–670, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. O.-H. Lee and B.-Y. Lee, “Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract,” Bioresource Technology, vol. 101, no. 10, pp. 3751–3754, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Bracci, L. Sebastiani, M. Busconi, C. Fogher, A. Belaj, and I. Trujillo, “SSR markers reveal the uniqueness of olive cultivars from the Italian region of Liguria,” Scientia Horticulturae, vol. 122, no. 2, pp. 209–215, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Mazzolini, S. Traverso, and C. Marchetti, “Multiple pathways of Pb2+ permeation in rat cerebellar granule neurones,” Journal of Neurochemistry, vol. 79, no. 2, pp. 407–416, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Grynkiewicz, M. Poenie, and R. Y. Tsien, “A new generation of Ca2+ indicators with greatly improved fluorescence properties,” Journal of Biological Chemistry, vol. 260, no. 6, pp. 3440–3450, 1985. View at Google Scholar · View at Scopus
  20. E. Ranzato, V. Magnelli, S. Martinotti et al., “Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels,” Cell Calcium, vol. 56, no. 4, pp. 285–295, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Li, J. B. Hansen, L. Huang, B. M. Keyser, and J. T. Taylor, “Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396,” Cardiovascular Drug Reviews, vol. 23, no. 2, pp. 173–196, 2005. View at Google Scholar · View at Scopus
  22. C. A. Palmerini, E. Carlini, C. Saccardi, M. Servili, G. Montedoro, and G. Arienti, “Activity of olive oil phenols on lymphomonocyte cytosolic calcium,” The Journal of Nutritional Biochemistry, vol. 16, no. 2, pp. 109–113, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Ranzato, S. Martinotti, V. Magnelli et al., “Epigallocatechin-3-gallate induces mesothelioma cell death via H2O2-dependent T-type Ca2+ channel opening,” Journal of Cellular and Molecular Medicine, vol. 16, no. 11, pp. 2667–2678, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Martinotti, E. Ranzato, and B. Burlando, “In vitro screening of synergistic ascorbate-drug combinations for the treatment of malignant mesothelioma,” Toxicology in Vitro, vol. 25, no. 8, pp. 1568–1574, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. D. T. Kremastinos, “Olive and oleuropein,” Hellenic Journal of Cardiology, vol. 49, no. 4, pp. 295–296, 2008. View at Google Scholar · View at Scopus
  26. Y. Wang, S. Q. Wang, W. H. Cui, J. J. He, Z. F. Wang, and X. L. Yang, “Olive leaf extract inhibits lead poisoning-induced brain injury,” Neural Regeneration Research, vol. 8, no. 22, pp. 2021–2029, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Tringham, K. L. Powell, S. M. Cain et al., “T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures,” Science translational medicine, vol. 4, no. 121, Article ID 121ra19, 2012. View at Publisher · View at Google Scholar
  28. A. Panner, L. L. Cribbs, G. M. Zainelli, T. C. Origitano, S. Singh, and R. D. Wurster, “Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells,” Cell Calcium, vol. 37, no. 2, pp. 105–119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. J. T. Taylor, X.-B. Zeng, J. E. Pottle et al., “Calcium signaling and T-type calcium channels in cancer cell cycling,” World Journal of Gastroenterology, vol. 14, no. 32, pp. 4984–4991, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Li, S.-L. Zhang, N. Wang, B.-B. Zhang, and M. Li, “Blockade of T-type Ca2+ channels inhibits human ovarian cancer cell proliferation,” Cancer Investigation, vol. 29, no. 5, pp. 339–346, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. K. R. Loughlin, “Calcium channel blockers and prostate cancer,” Urologic Oncology, vol. 32, no. 5, pp. 537–538, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. G. E. Bertolesi, C. Shi, L. Elbaum et al., “The Ca2+ channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms,” Molecular Pharmacology, vol. 62, no. 2, pp. 210–219, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. G. R. Monteith, D. McAndrew, H. M. Faddy, and S. J. Roberts-Thomson, “Calcium and cancer: targeting Ca2+ transport,” Nature Reviews Cancer, vol. 7, no. 7, pp. 519–530, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Scheffler, H. W. Rauwald, B. Kampa, U. Mann, F. W. Mohr, and S. Dhein, “Olea europaea leaf extract exerts L-type Ca2+ channel antagonistic effects,” Journal of Ethnopharmacology, vol. 120, no. 2, pp. 233–240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. A. H. Gilani, A.-U. Khan, A. J. Shah, J. Connor, and Q. Jabeen, “Blood pressure lowering effect of olive is mediated through calcium channel blockade,” International Journal of Food Sciences and Nutrition, vol. 56, no. 8, pp. 613–620, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. R. I. Geran, N. H. Greenberg, M. M. Macdonald, A. M. Shumacher, and B. J. Abbott, “Protocols for screening chemical agents and natural products against animal tumors and other biological systems,” Cancer Chemotherapy Reports Part 3, vol. 3, pp. 1–103, 1972. View at Google Scholar
  37. M. Suganuma, A. Saha, and H. Fujiki, “New cancer treatment strategy using combination of green tea catechins and anticancer drugs,” Cancer Science, vol. 102, no. 2, pp. 317–323, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Visioli and C. Galli, “Phenolics from olive oil and its waste products. Biological activities in in vitro and in vivo studies,” World Review of Nutrition and Dietetics, vol. 88, pp. 233–237, 2001. View at Google Scholar · View at Scopus
  39. P. González, F. Florido, B. Sáenz de San Pedro, F. de la Torre, P. Rico, and S. Martín, “Immunotherapy with an extract of Olea europaea quantified in mass units: evaluation of the safety and efficacy after one year of treatment,” Journal of Investigational Allergology and Clinical Immunology, vol. 12, no. 4, pp. 263–271, 2002. View at Google Scholar · View at Scopus
  40. M. de Bock, E. B. Thorstensen, J. G. B. Derraik, H. V. Henderson, P. L. Hofman, and W. S. Cutfield, “Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract,” Molecular Nutrition and Food Research, vol. 57, no. 11, pp. 2079–2085, 2013. View at Publisher · View at Google Scholar · View at Scopus