Research Article
Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis
Table 2
Anticancer effects of compounds 1–5 isolated from Flourensia oolepis extract toward sensitive and resistant leukemic cells.
| | Compounds | IC50 (μM) values and 95% confidence limits (lower, upper) | | CCRF-CEM | CEM/ADR5000 | K562 | Lucena 1 |
| | 2′,4′-Dihydroxychalcone () | 6.6 (3.3–14.1) | 9.9 (5.8–18.3) | 27.5 (14.6–52.0) | 30.0 (14.6–64.9) | | Isoliquiritigenin () | 58.1 (22.6–148.7) | 51.9 (26.9–99.1) | >100 | >100 | | Pinocembrin () | 58.9 (16.4–210.3) | 53.5 (19.5–145.9) | >100 | >100 | | 7-Hydroxyflavanone () | 72.8 (30.0–175.2) | 66.2 (27.5–160.7) | >100 | >100 | | 7,4′-Dihydroxy-3′-methoxyflavanone () | 24.8 (10.8–57.3) | 30.4 (15.4–60.1) | >100 | >100 | | Doxorubicin | 0.133 (0.0–0.3) | >69 | 4.1 (1.6–11.4) | >69 |
|
|
