Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 913158, 5 pages
http://dx.doi.org/10.1155/2015/913158
Research Article

The Effect of Korean Red Ginseng on Sexual Function in Premenopausal Women: Placebo-Controlled, Double-Blind, Crossover Clinical Trial

Department of Urology, Chonnam National University, 671 Jebongno, Donggu, Gwangju 61469, Republic of Korea

Received 17 August 2015; Accepted 19 November 2015

Academic Editor: David Mischoulon

Copyright © 2015 Ho Seok Chung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. O. Laumann, A. Paik, and R. C. Rosen, “Sexual dysfunction in the United States: prevalence and predictors,” The Journal of the American Medical Association, vol. 281, no. 6, pp. 537–544, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Goshtasebi, M. Vahdaninia, and A. R. Foroshani, “Prevalence and potential risk factors of female sexual difficulties: an urban Iranian population-based study,” Journal of Sexual Medicine, vol. 6, no. 11, pp. 2988–2996, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Basson, J. Berman, A. Burnett et al., “Report of the international consensus development conference on female sexual dysfunction: definitions and classifications,” The Journal of Urology, vol. 163, no. 3, pp. 888–893, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Incrocci and P. T. Jensen, “Pelvic radiotherapy and sexual function in men and women,” Journal of Sexual Medicine, vol. 10, supplement 1, pp. 53–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. C. M. Dording, R. A. LaRocca, K. A. Hails et al., “The effect of sildenafil on quality of life,” Annals of Clinical Psychiatry, vol. 25, no. 1, pp. 3–10, 2013. View at Google Scholar · View at Scopus
  6. M. J. Bly, J. R. Bishop, K. L. H. Thomas, and V. L. Ellingrod, “P-glycoprotein (PGP) polymorphisms and sexual dysfunction in female patients with depression and SSRI-associated sexual side effects,” Journal of Sex and Marital Therapy, vol. 39, no. 3, pp. 280–288, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Kashani, F. Raisi, S. Saroukhani et al., “Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study,” Human Psychopharmacology, vol. 28, no. 1, pp. 54–60, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Bradford, “Listening to placebo in clinical trials for female sexual dysfunction,” Journal of Sexual Medicine, vol. 10, no. 2, pp. 451–459, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Wylie and F. Malik, “Review of drug treatment for female sexual dysfunction,” International Journal of STD and AIDS, vol. 20, no. 10, pp. 671–674, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. W. Chan, “Panax ginseng, Rhodiola rosea and Schisandra chinensis,” International Journal of Food Sciences and Nutrition, vol. 63, supplement 1, pp. 75–81, 2012. View at Publisher · View at Google Scholar
  11. J. H. Jung, I. G. Kang, D. Y. Kim, Y. J. Hwang, and S. T. Kim, “The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis,” Journal of Ginseng Research, vol. 37, no. 2, pp. 167–175, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. K.-J. Oh, M.-J. Chae, H.-S. Lee, H.-D. Hong, and K. Park, “Effects of korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study,” Journal of Sexual Medicine, vol. 7, no. 4, part 1, pp. 1469–1477, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. D. Choi, C. W. Park, J. Jang et al., “Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study,” International Journal of Impotence Research, vol. 25, no. 2, pp. 45–50, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. S.-Y. Han, H.-X. Li, X. Ma et al., “Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats,” Journal of Ethnopharmacology, vol. 145, no. 3, pp. 722–727, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Lee, D. Park, and M. Yoon, “Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice,” Food and Chemical Toxicology, vol. 53, pp. 402–408, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Liu, W. Li, X. Li et al., “Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin,” Journal of Ethnopharmacology, vol. 145, no. 1, pp. 233–240, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. Y.-H. Kim, G.-H. Kim, J.-H. Shin, K.-S. Kim, and J.-S. Lim, “Effect of Korean red ginseng on testicular tissue injury after torsion and detorsion,” Korean Journal of Urology, vol. 51, no. 11, pp. 794–799, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. S.-O. Kim, M. K. Kim, H.-S. Lee, J. K. Park, and K. Park, “The effect of Korean red ginseng extract on the relaxation response in isolated rabbit vaginal tissue and its mechanism,” Journal of Sexual Medicine, vol. 5, no. 9, pp. 2079–2084, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. S. O. Kim, M. Lee, Y. Xui et al., “Effects of Korean red ginseng on the vaginal blood flow and sturcture in female casttrated rats,” Korean Journal of Urology, vol. 47, no. 8, pp. 888–894, 2006. View at Google Scholar
  20. R. Rosen, C. Brown, J. Heiman et al., “The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function,” Journal of Sex and Marital Therapy, vol. 26, no. 2, pp. 191–208, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Y. Kim, H. S. So, K. S. Park, S. J. Jeong, J. Y. Lee, and S. B. Ryu, “Development of the Korean-version of female sexual function index (FSFI),” Korean Journal of Andrology, vol. 20, no. 1, pp. 50–56, 2002. View at Google Scholar
  22. C. Günzler and M. M. Berner, “Efficacy of psychosocial interventions in men and women with sexual dysfunctions—a systematic review of controlled clinical trials. Part 2. The efficacy of psychosocial interventions for female sexual dysfunction,” Journal of Sexual Medicine, vol. 9, no. 12, pp. 3108–3125, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. B. S. Christensen, M. Grønbæk, M. Osler, B. V. Pedersen, C. Graugaard, and M. Frisch, “Associations between physical and mental health problems and sexual dysfunctions in sexually active danes,” Journal of Sexual Medicine, vol. 8, no. 7, pp. 1890–1902, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. R. Leiblum, P. E. Koochaki, C. A. Rodenberg, I. P. Barton, and R. C. Rosen, “Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS),” Menopause, vol. 13, no. 1, pp. 46–56, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. U. Hartmann, K. Heiser, C. Rüffer-Hesse, and G. Kloth, “Female sexual desire disorders: subtypes, classification, personality factors and new directions for treatment,” World Journal of Urology, vol. 20, no. 2, pp. 79–88, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Hong, Y. H. Ji, J. H. Hong, K. I. Y. Nam, and T. Y. Ahn, “A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report,” The Journal of Urology, vol. 168, no. 5, pp. 2070–2073, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. D.-J. Jang, M. S. Lee, B.-C. Shin, Y.-C. Lee, and E. Ernst, “Red ginseng for treating erectile dysfunction: a systematic review,” British Journal of Clinical Pharmacology, vol. 66, no. 4, pp. 444–450, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Tachikawa, K. Kudo, K. Harada et al., “Effects of ginseng saponins on responses induced by various receptor stimuli,” European Journal of Pharmacology, vol. 369, no. 1, pp. 23–32, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. J. R. Roney and Z. L. Simmons, “Hormonal predictors of sexual motivation in natural menstrual cycles,” Hormones and Behavior, vol. 63, no. 4, pp. 636–645, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Y. Kim, S. K. Seo, Y. M. Choi et al., “Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial,” Menopause, vol. 19, no. 4, pp. 461–466, 2012. View at Publisher · View at Google Scholar · View at Scopus