Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds

Figure 1

Effects of oral administration of E, H, EA, or B fractions of Pereskia bleo Kunth leaves on the hot plate model. Control groups were composed of vehicle or morphine (5 mg/kg, p.o.). Results are presented as mean ± S.D. (–10) of increase in baseline or area under the curve. Statistical significance was calculated by ANOVA with Bonferroni’s test where when comparing morphine, ethanol extract, hexane, ethyl acetate, or butanol fractions-treated mice with vehicle-treated group and when comparing E, H, EA, or B fractions-treated group with morphine-treated group. Where no error bars are shown, this is because the error bars are so small that they cannot be seen in the graphic.