Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds

Table 1

Effects of ethanol extract, hexane, ethyl acetate, and butanol fractions on spontaneous activity mice.

	Hour after treatment
	0.5	1	2	4
Spontaneous activity
Vehicle	55 ± 6.8	62.4 ± 7.1	59.1 ± 6.7	53.9 ± 6.4
E	60.8 ± 9.7	65.7 ± 9.9	52.4 ± 6.9	56.7 ± 8.1
H	51.9 ± 7.7	58.3 ± 8.6	55.4 ± 10.1	60.3 ± 7.2
EA	66.1 ± 11.6	61.7 ± 9.3	54.6 ± 7.8	49.8 ± 8.1
B	51.9 ± 6.9	59.9 ± 8.7	66.1 ± 7.8	48.4 ± 6.8
Locomotor performance
Vehicle	12 ± 1.3	15.4 ± 3.3	14.7 ± 2.8	19.7 ± 2.6
E	8.9 ± 3.1	12.7 ± 3.1	13.9 ± 4.2	15.3 ± 4.8
H	9.9 ± 1.8	14.7 ± 2.1	16.7 ± 2.9	17.6 ± 2.7
EA	11.4 ± 3.1	16.7 ± 1.9	15.5 ± 2.4	16.8 ± 1.9
B	10.7 ± 3.1	12.5 ± 3.8	15.4 ± 4.4	21.8 ± 5.2

Results are presented as mean ± S.D. ( = 6–10).