Gene Expression Profiling and Pathway Network Analysis Predicts a Novel Antitumor Function for a Botanical-Derived Drug, PG2

Table 1

Statistics for the PG2 gene signature from different product batches.

PG2 versus vehicle
	PG2-6J1	PG2-6J2	PG2-9J1
Number of PG2 microarray	4	4	3
probe sets
t-test
Upregulated	284	533	332
Downregulated	122	369	227
Total number of probe sets	406	902	559
Excluded multiple or no gene symbol	307	666	418
		1,154
Limma
Total number of probe sets	388	1836	1272
Excluded multiple or no gene symbol	297	1272	936
		2,008
Gene
Limma
Gene symbols	158	617	484
		991
t-test
Gene symbols	290	638	404
		1,111
		Up: 646/Down: 465
Differentially expressed genes	Up: 27/Down: 5
-clique gene symbols		Up: 65/Down: 22
3-clique: 27; 4-clique: 10	Up: 44/Down: 17

A total of 11 PG2 microarrays were conducted in this study and divided into three product batches: 6J1, 6J2, and 9J1.