Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

<div>CUR treatment delays the Ca<sup>2+</sup>-dependent mitochondrial permeability transition in renal cortex of GM-exposed rats. (a) Representative tracings of Ca<sup>2+</sup> retention capacity obtained by arsenazo III assay and (b) representative tracings of mitochondrial membrane potential responsive to Ca<sup>2+</sup> overload obtained by safranin O assay. CCCP: carbonyl cyanide m-chlorophenylhydrazone; CT: control; GM: gentamicin; CUR: curcumin; CsA: cyclosporine A.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 10

Figure 10: Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism 