Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

Figure 2

CUR induces an increase in nuclear accumulation of Nrf2 and prevented the GM-induced drop in Nrf2 expression and nuclear accumulation in LLC-PK1 cells. Cells were preincubated with 30 μM CUR during 24 h and then coincubated with 30 μM CUR and 8 mM GM during further 48 h. Expression of Nrf2 was detected by immunocytochemical technique. (a) CT. (b) GM. (c) CUR + GM. (d) CUR. (e) Quantification of positive nuclei. Data are mean ± SEM, . versus CT; versus GM.

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