Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

Figure 3

CUR prevents GM-induced drop in expression of the coactivator PGC-1α in LLC-PK1 cells. Cells were preincubated with 30 μM CUR during 24 h and then coincubated with 30 μM CUR and 8 mM GM during further 48 h. Expression of PGC-1α was detected by immunocytochemical technique. (a) CT. (b) GM. (c) CUR + GM. (d) CUR. (e) Quantification of positive cells. Data are mean ± SEM, . versus CT; versus GM.

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