Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

Figure 6

Representative tracings for oxygen consumption profiles of renal mitochondria using (a) malate/glutamate or (b) succinate as substrates. Values on tracings belong to punctual observations and are not means. M: mitochondria; ADP: adenosine diphosphate; CCCP: carbonyl cyanide m-chlorophenylhydrazone; S3: state 3; S4: state 4; UC: uncoupled respiration; CT: control; GM: gentamicin; CUR: curcumin. Units of S3, S4, and UC are ngAtO/min/mg protein.

(a)

(b)