The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

<div>Experimental protocol for the animal study. Closed and open arrows indicate the intraperitoneal (i.p.) injections of lipopolysaccharide (LPS) and oral administration of Kampo formulations. Striped arrow indicates the administration of Evans blue (EB) dye or oseltamivir phosphate (OP). The concentrations of EB were determined 120 min after the intravenous injection. The concentrations of oseltamivir and oseltamivir carboxylate (OC) were determined at 5, 60, and 120 min following OP administration.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 

Figure 1 | The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 