The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/ecam/volume-2015/917670/figures/917670.fig.006a.svgz" name="917670.fig.006a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Plasma</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/ecam/volume-2015/917670/figures/917670.fig.006b.svgz" name="917670.fig.006b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Brain</td></tr></table>

<div>Plasma (a) and brain (b) concentrations versus time profiles of oseltamivir carboxylate (OC) after the administration of OC to mice with lipopolysaccharide- (LPS-) induced inflammation. Mice were pretreated with three intraperitoneal (i.p.) injections of LPS (3 mg/kg) with concurrent oral administration of (●) saline, (□) maoto, or (△) kakkonto. Control animals were administered saline vehicle without LPS (○). A single intravenous dose of OC (20 mg/kg) was administered to mice 120 min after the third injection of LPS.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 6

Figure 6: The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 

Figure 6 | The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 