The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

Table 2

Amounts of marker constituent compounds in kakkonto and maoto extract formulations.

Kampo formulation	Maker compound for QC	Amount listed in JP16 (in 7.5 g)	Amount per lot (in 7.5 g)
			H44002	J26252
Kakkonto	Glycyrrhizic acid	19–57 mg	27.7 ± 0.2 mg	25.8 ± 0.36 mg
	Paeoniflorin	14–56 mg	27.7 ± 0.4 mg	30.4 ± 0.63 mg
			F47711	J04981
Maoto	Glycyrrhizic acid	14–42 mg	31.1 ± 0.46 mg	31.1 ± 0.25 mg
	Amygdalin	48–192 mg	102.7 ± 2.87 mg	90.4 ± 3.66 mg

Data represent the mean ± S.D. ().