The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

Table 3

The and the mean brain-to-plasma ratio (BPR) of oseltamivir and oseltamivir carboxylate (OC) following oral administration of oseltamivir phosphate (OP) to mice with lipopolysaccharide- (LPS-) induced inflammation.

Group	AUC				BPR
	Plasma (min·g/mL)		Brain (min·g/g brain)		(L/g brain)
	Oseltamivir	OC	Oseltamivir	OC	Oseltamivir	OC
Con	1949.86	762.01	79.35	16.06	40.70	21.08
Mao	3749.85	856.89	119.92	18.95	31.98	22.12
Kak	5066.10	1199.90	200.21	5.98	39.52	4.98

Con: control; Kak: kakkonto-treated; Mao: maoto-treated.