The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

Table 4

Blood biochemistry parameters in mice with lipopolysaccharide- (LPS-) induced inflammation.

Parameter	(units)	Con	Mao	Kak
ALP	U/L	51.4 ± 47.96	25.5 ± 9.57	33.6 ± 7.57
ALT	U/L	71.2 ± 33.81	61.5 ± 14.29	69.6 ± 8.08
AMY	U/L	1058.2 ± 240.48	796.2 ± 63.24	949.8 ± 225.76
CRE	mg/dL	0.5 ± 0.24	<0.2	<0.2
BUN	mg/dL	75.8 ± 51.91	70.7 ± 24.71	59.4 ± 9.42
TP	g/dL	5.3 ± 0.23	5.0 ± 0.33	5.0 ± 0.13
ALB	g/dL	2.7 ± 0.17	2.7 ± 0.15	2.6 ± 0.14
TBIL	mg/dL	0.3 ± 0.04	0.2 ± 0.09	0.2 ± 0.05
Na+	mmol/L	145.8 ± 6.14	141.3 ± 3.67	139.4 ± 2.97
K+	mmol/L	6.9 ± 1.10	7.2 ± 1.39	7.3 ± 1.07
Ca++	mg/dL	9.4 ± 0.22	9.1 ± 0.45	8.9 ± 0.37
PHOS	mg/dL	10.2 ± 3.13	9.4 ± 1.73	10.2 ± 0.82
GLU	mg/dL	33.6 ± 19.81	69.3 ± 10.56^*	65.4 ± 6.99^*

Data represent the mean ± S.D. ().
(versus control).
^#Below the limit of quantitation.