Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.

Table 3

The metabolic activity of single and mixed biofilms when exposed to bakuchiol was measured. Values represent absorbance using XTT reduction assay.

Biofilms	Untreated	Bakuchiol	Amphotericin B
Single species
C. albicans	1.042 ± 0.049^†	0.417 ± 0.085^α	0.266 ± 0.046^α,β
C. dubliniensis	0.279 ± 0.016	0.274 ± 0.029	0.174 ± 0.026^α,β
C. glabrata	0.723 ± 0.040^†	0.896 ± 0.096	0.353 ± 0.061^α,β
C. krusei	0.467 ± 0.048	0.400 ± 0.085	0.228 ± 0.079^α,β
C. lusitaniae	0.192 ± 0.016	0.182 ± 0.017	0.242 ± 0.030^α,β
C. tropicalis	0.351 ± 0.037	0.243 ± 0.032^α	0.376 ± 0.056^β
Mixed species
C. albicans
+ C. dubliniensis	0.435 ± 0.024	0.205 ± 0.015^α	0.201 ± 0.023^α
+ C. glabrata	1.023 ± 0.054^†	0.962 ± 0.104	0.527 ± 0.036^α,β
+ C. krusei	0.444 ± 0.014	0.315 ± 0.018^α	0.330 ± 0.032^β
+ C. lusitaniae	0.292 ± 0.013	0.246 ± 0.014	0.232 ± 0.025
+ C. tropicalis	0.289 ± 0.019	0.210 ± 0.025	0.198 ± 0.015^β

 ^† compared to others in their respective groups; single and mixed species biofilms.
^α compared to the untreated samples.
^β compared to bakuchiol-treated samples.