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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 921306, 10 pages
http://dx.doi.org/10.1155/2015/921306
Research Article

Xanthohumol Induces Growth Inhibition and Apoptosis in Ca Ski Human Cervical Cancer Cells

Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 10 December 2014; Revised 5 February 2015; Accepted 25 February 2015

Academic Editor: Abid Hamid

Copyright © 2015 Wai Kuan Yong and Sri Nurestri Abd Malek. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. T. Gómez and J. L. Santos, “Human papillomavirus infection and cervical cancer: pathogenesis and epidemiology,” in Communicating Current Research and Educational Topics and Trends in Applied Microbiology, A. Méndez-Vilas, Ed., pp. 680–688, Formatex Research Center, Badajoz, Spain, 2007. View at Google Scholar
  2. T. Yugawa and T. Kiyono, “Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins,” Reviews in Medical Virology, vol. 19, no. 2, pp. 97–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. International Agency for Research on Cancer, GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012, International Agency for Research on Cancer, 2012, http://globocan.iarc.fr/Default.aspx.
  4. F. Zagouri, T. N. Sergentanis, D. Chrysikos, M. Filipits, and R. Bartsch, “Molecularly targeted therapies in cervical cancer. A systematic review,” Gynecologic Oncology, vol. 126, no. 2, pp. 291–303, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Strathmann and C. Gerhauser, “Anti-proliferative and apoptosis-inducing properties of xanthohumol, a prenylated chalcone from hops (Humulus lupulus L.),” in Natural Compounds as Inducers of Cell Death, M. Diederich and K. Noworyta, Eds., pp. 69–93, Springer, Dordrecht, The Netherlands, 2012. View at Google Scholar
  6. R. Monteiro, H. Becker, I. Azevedo, and C. Calhau, “Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity,” Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 2938–2943, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Gerhauser, A. Alt, E. Heiss et al., “Cancer chemopreventive activity of xanthohumol, a natural product derived from hop,” Molecular Cancer Therapeutics, vol. 1, no. 11, pp. 959–969, 2002. View at Google Scholar · View at Scopus
  8. S. Guerreiro, R. Monteiro, M. J. Martins, C. Calhau, I. Azevedo, and R. Soares, “Distinct modulation of alkaline phosphatase isoenzymes by 17β-estradiol and xanthohumol in breast cancer MCF-7 cells,” Clinical Biochemistry, vol. 40, no. 3-4, pp. 268–273, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Monteiro, C. Calhau, A. O. E. Silva et al., “Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts,” Journal of Cellular Biochemistry, vol. 104, no. 5, pp. 1699–1707, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Vogel, S. Ohmayer, G. Brunner, and J. Heilmann, “Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity,” Bioorganic and Medicinal Chemistry, vol. 16, no. 8, pp. 4286–4293, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Szliszka, D. Jaworska, M. Kłósek, Z. P. Czuba, and W. Król, “Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells,” International Journal of Molecular Sciences, vol. 13, no. 11, pp. 15343–15359, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Wen, D. Li, Y. Zhang, S. Liu, L. Ghali, and R. K. Iles, “Arsenic trioxide induces cervical cancer apoptosis, but specifically targets human papillomavirus-infected cell populations,” Anti-Cancer Drugs, vol. 23, no. 3, pp. 280–287, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. D. Meissner, “Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines,” Journal of General Virology, vol. 80, no. 7, pp. 1725–1733, 1999. View at Google Scholar · View at Scopus
  14. P. Houghton, R. Fang, I. Techatanawat, G. Steventon, P. J. Hylands, and C. C. Lee, “The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity,” Methods, vol. 42, no. 4, pp. 377–387, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. S. H. Lee, H. J. Kim, J. S. Lee, I.-S. Lee, and B. Y. Kang, “Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol from hops,” Archives of Pharmacal Research, vol. 30, no. 11, pp. 1435–1439, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. W. A. Cliby, K. A. Lewis, K. K. Lilly, and S. H. Kaufmann, “S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function,” The Journal of Biological Chemistry, vol. 277, no. 2, pp. 1599–1606, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Pan, H. Becker, and C. Gerhäuser, “Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway,” Molecular Nutrition and Food Research, vol. 49, no. 9, pp. 837–843, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Vanhoecke, L. Derycke, V. Van Marck, H. Depypere, D. De Keukeleire, and M. Bracke, “Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer,” International Journal of Cancer, vol. 117, no. 6, pp. 889–895, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Motoyama, C. A. Ladines-Llave, S. L. Villanueva, and T. Maruo, “The role of human papilloma virus in the molecular biology of cervical carcinogenesis,” Kobe Journal of Medical Sciences, vol. 50, no. 1-2, pp. 9–19, 2004. View at Google Scholar · View at Scopus
  20. M. C. de Almagro and D. Vucic, “The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy,” Experimental Oncology, vol. 34, no. 3, pp. 200–211, 2012. View at Google Scholar · View at Scopus
  21. K. B. Harikumar, A. B. Kunnumakkara, K. S. Ahn et al., “Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB-regulated gene products and potentiation of apoptosis in leukemia cells,” Blood, vol. 113, no. 9, pp. 2003–2013, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Norberg, S. Orrenius, and B. Zhivotovsky, “Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF),” Biochemical and Biophysical Research Communications, vol. 396, no. 1, pp. 95–100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Strathmann, K. Klimo, S. W. Sauer, J. G. Okun, J. H. M. Prehn, and C. Gerhäuser, “Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism,” The FASEB Journal, vol. 24, no. 8, pp. 2938–2950, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Chen, A. D. Guerrero, L. Huang et al., “Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members,” The Journal of Biological Chemistry, vol. 282, no. 46, pp. 33888–33895, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Mahyar-Roemer, H. Köhler, and K. Roemer, “Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells,” BMC Cancer, vol. 2, article 27, 9 pages, 2002. View at Publisher · View at Google Scholar
  26. X. Lei, Y. Chen, G. Du et al., “Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2,” The FASEB Journal, vol. 20, no. 12, pp. 2147–2149, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. F. W. Kah, S.-L. Chan, S. K. Sukumaran, M.-C. Lee, and V. C. Yu, “Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism,” The Journal of Biological Chemistry, vol. 283, no. 13, pp. 8423–8433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Gowthamarajan, R. Shanmugam, K. Madhuri, P. Nilani, M. Satish Kumar, and L. Dwarampudi, “The potential therapeutic targets for cervical cancer,” International Journal of Health & Allied Sciences, vol. 2, no. 2, pp. 69–74, 2013. View at Publisher · View at Google Scholar
  29. N. Zhang, Z. Liu, Q. Han et al., “Inhibition of bovine viral diarrhea virus in vitro by xanthohumol: comparisons with ribavirin and interferon-α and implications for the development of anti-hepatitis C virus agents,” European Journal of Pharmaceutical Sciences, vol. 38, no. 4, pp. 332–340, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. B. W. Vanhoecke, F. Delporte, E. van Braeckel et al., “A safety study of oral tangeretin and xanthohumol administration to laboratory mice,” In Vivo, vol. 19, no. 1, pp. 103–108, 2005. View at Google Scholar · View at Scopus
  31. R. Hussong, N. Frank, J. Knauft et al., “A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats,” Molecular Nutrition and Food Research, vol. 49, no. 9, pp. 861–867, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. R. B. van Breemen, Y. Yuan, S. Banuvar et al., “Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops,” Molecular Nutrition & Food Research, vol. 58, no. 10, pp. 1962–1969, 2014. View at Publisher · View at Google Scholar