Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.

Table 2

MIC values (μg/mL) of drugs in the absence and presence of sorbitol (0.8 M) and ergosterol (400 μg/mL) against Aspergillus spp.

Microorganisms	MIC values (μg/mL)
	A. fumigatus; ATCC 46913	A. flavus; ATCC 16013	A. fumigatus; ATCC 46913	A. flavus; ATCC 16013	A. fumigatus; ATCC 46913	A. flavus; ATCC 16013
Drugs	−Sterols		+Sorbitol		+Ergosterol
Cou-UNO2	16	16	256	256	16	16
Amphotericin B	2	2	—	—	16	16
Fluconazole	256	512	512	512	256	512

Note. Cou-UNO₂: 7-hydroxy-6-nitro-2H-1-benzopyran-2-one.