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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 925432, 9 pages
http://dx.doi.org/10.1155/2015/925432
Research Article

The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice

1Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
2Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 570-749, Republic of Korea
3Department of Pharmacology, School of Medicine, Eulji University, Jung-gu, Daejeon 301-746, Republic of Korea
4Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
5Hanpoong Pharm & Foods Co., Ltd., Jeonju 561-841, Republic of Korea
6Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, Iksan 570-749, Republic of Korea

Received 25 August 2015; Accepted 11 October 2015

Academic Editor: Hassan Obied

Copyright © 2015 Samrat Baral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myrrh has been used since ancient times for the treatment of various diseases such as inflammatory diseases, gynecological diseases, and hemiplegia. In the present study, we investigated the effects of aqueous extracts of myrrh resin (AEM) on scopolamine-induced memory impairments in mice. AEM was estimated with (2E,5E)-6-hydroxy-2,6-dimethylhepta-2,4-dienal as a representative constituent by HPLC. The oral administration of AEM for 7 days significantly reversed scopolamine-induced reduction of spontaneous alternation in the -maze test. In the passive avoidance task, AEM also restored the decreased latency time of the retention trial by scopolamine treatment. In addition, Western blot analysis and Immunohistochemistry revealed that AEM reversed scopolamine-decreased phosphorylation of Akt and extracellular signal-regulated kinase (ERK). Our study demonstrates for the first time that AEM ameliorates the scopolamine-induced memory impairments in mice and increases the phosphorylation of Akt and ERK in the hippocampus of mice brain. These results suggest that AEM has the therapeutic potential in memory impairments.