The Effect of Crocus sativus L. and Its Constituents on Memory: Basic Studies and Clinical Applications

Table 2

Summary of clinical trials on Crocus sativus L., as treatment for AD.  

Design of study	Duration of study	Severity of disease	Agent	Dose range	Route	Effect	Reference
Double-blind	16 weeks	Mild-to-moderate AD	C. sativus	30 mg/day	p.o.	Safe and with certain efficacy	[56]
Double-blind	22 weeks	Mild-to-moderate AD	C. sativus; Donepezil	30 mg/day; 10 mg/day	p.o.; p.o.	Similar efficacy and better safety profile compared to donepezil	[57]
Double-blind	12 weeks	Moderate-to-severe AD	C. sativus; Memantine	30 mg/day; 20 mg/day	p.o.; p.o.	Similar efficacy and safety profile compared to memantine	[58]

AD, Alzheimer’s disease; C. sativus, Crocus sativus L.; p.o., orally.