Tongxinluo Prevents Endothelial Dysfunction Induced by Homocysteine Thiolactone In Vivo via Suppression of Oxidative Stress

Figure 5

TXL suppresses oxidative stress and improves endothelial functions in rats fed with HTL in vivo. The rats were intragastric gavage HTL (50 mg/kg/d) and received administration of TXL (1.0 g/kg/d) for 8 weeks. At the end of experiments, rats were sacrificed under anesthesia. Artery from descending aorta was subjected to assay (a) endothelium-dependent relaxation induced by acetylcholine (Ach) and (b) endothelium-independent relaxation induced by sodium nitroprusside (SNP) in organ chamber. Blood was collected to assay serum level of (c) NO by Griess method and (d) MDA by TBA method. All data were expressed as mean ± SEM, 5–10 rats in each group. versus Con and versus HTL alone.

(a)

(b)

(c)

(d)