Polypeptide Fraction from <i>Arca subcrenata</i> Induces Apoptosis and G2/M Phase Arrest in HeLa Cells via ROS-Mediated MAPKs Pathways

<div>Proposed molecular mechanism of P2 included apoptosis induction and G2/M phase arrest via ROS-mediated MAPKs pathways in HeLa cells. <svg height="6.44133pt" id="M14" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -6.39151 17.4283 6.44133" width="17.4283pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,2.205,0)"><path d="M935 263C895 299 821 372 745 456L719 439L824 289H72V236H823L719 87L745 70C821 154 895 227 935 263Z" id="g54-148"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="990" vert-adv-y="990"></glyph.data></g></svg> represents activation while <svg height="9.12935pt" id="M15" style="vertical-align:-1.14589pt" version="1.1" viewbox="-0.0498162 -7.98346 7.40695 9.12935" width="7.40695pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M486 -27V552H424V289H37V236H424V-27H486Z" id="g54-172"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="560" vert-adv-y="560"></glyph.data></g></svg> represents inactivation. The molecular mechanism of the antitumor activity of P2 was proposed according to the results obtained by MTT, FCM, LSCM, and western blot assays.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 7

Figure 7: Polypeptide Fraction from <i>Arca subcrenata</i> Induces Apoptosis and G2/M Phase Arrest in HeLa Cells via ROS-Mediated MAPKs Pathways 

Evidence-Based Complementary and Alternative Medicine

Polypeptide Fraction from Arca subcrenata Induces Apoptosis and G2/M Phase Arrest in HeLa Cells via ROS-Mediated MAPKs Pathways

Figure 7