The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats
Table 2
Effects of lacidipine on left ventricular mass index.
Group
BW (g)
LVW (g)
LVMI (×10−3)
Normal blank group
305.1 ± 11.48
0.66 ± 0.08
2.15 ± 0.08
SHR control group
322.6 ± 9.86
1.06 ± 0.11**
3.26 ± 0.16**
Captopril positive control group
316.1 ± 10.86
0.92 ± 0.09##
2.91 ± 0.11#
Lacidipine 1.44 mg/kg group
320.5 ± 11.08
1.03 ± 0.10
3.19 ± 0.14
Lacidipine 0.72 mg/kg group
315.2 ± 10.18
0.89 ± 0.09##
2.84 ± 0.11#
Lacidipine 0.36 mg/kg group
317.8 ± 10.62
0.96 ± 0.10#
3.02 ± 0.12
BW: body weight, LVW: left ventricles weight, and LVMI: left ventricular mass index; * < 0.05, ** < 0.01 compared with normal blank group; # < 0.05, ## < 0.01 compared with SHR control group.
