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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 950829, 7 pages
http://dx.doi.org/10.1155/2015/950829
Research Article

Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage

1Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2Department of Life and Nanopharmaceutical Science, Graduates School and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
3Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
4R&D Center, Kwang Dong Pharmaceutical Co., Ltd., 621-1 Jangdang-dong, Pyongtaek-si, Kyonggi-do 459-020, Republic of Korea

Received 26 June 2015; Revised 7 September 2015; Accepted 10 September 2015

Academic Editor: Angelo A. Izzo

Copyright © 2015 Deok-Sang Hwang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jungwirth, A. Giwercman, H. Tournaye et al., “European association of urology guidelines on male infertility: the 2012 update,” European Urology, vol. 62, no. 2, pp. 324–332, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Gao, Y. Zuo, K. So, W. S. Yeung, E. H. Ng, and K. Lee, “Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment,” Spermatogenesis, vol. 2, no. 1, pp. 53–62, 2012. View at Publisher · View at Google Scholar
  3. G. R. Dohle, D. J. J. Halley, J. O. Van Hemel et al., “Genetic risk factors in infertile men with severe oligozoospermia and azoospermia,” Human Reproduction, vol. 17, no. 1, pp. 13–16, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. S. A. Kidd, B. Eskenazi, and A. J. Wyrobek, “Effects of male age on semen quality and fertility: a review of the literature,” Fertility and Sterility, vol. 75, no. 2, pp. 237–248, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Oliva, A. Spira, and L. Multigner, “Contribution of environmental factors to the risk of male infertility,” Human Reproduction, vol. 16, no. 8, pp. 1768–1776, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Jung and H.-C. Schuppe, “Influence of genital heat stress on semen quality in humans,” Andrologia, vol. 39, no. 6, pp. 203–215, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Hur, Donguibogam, Translated Edition by a Committee for Translation, Bupin Publishes, Seoul, Republic of Korea, 1999.
  8. M. D. Kim, “The literature study on the effecacy and manufacturing proecss of gyeongoggo,” The Journal of Oriental Medical Classics, vol. 24, no. 2, pp. 51–64, 2011. View at Google Scholar
  9. S. Lee, Y. Shin, J. Park, S. Kim, and C. Park, “An analysis of the gyungokgo's ingredients and a comparison study on anti-oxidation effects according to the kinds of extract,” The Korea Journal of Herbology, vol. 23, no. 2, pp. 123–136, 2008. View at Google Scholar
  10. L.-R. Im, J.-Y. Ahn, J.-H. Kim et al., “Inhibitory effect of Kyungohkgo in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice,” Archives of Pharmacal Research, vol. 34, no. 2, pp. 317–321, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. L. B. Nachtigall, P. A. Boepple, F. P. Pralong, and W. F. Crowley Jr., “Adult-onset idiopathic hypogonadotropic hypogonadism—a treatable form of male infertility,” The New England Journal of Medicine, vol. 336, no. 6, pp. 410–415, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Koca, Ö. L. Özdal, M. Çelik, S. Ünal, and N. Balaban, “Antioxidant activity of seminal plasma in fertile and infertile men,” Systems Biology in Reproductive Medicine, vol. 49, no. 5, pp. 355–359, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. S. La Vignera, R. A. Condorelli, E. Vicari et al., “Microbiological investigation in male infertility: a practical overview,” Journal of Medical Microbiology, vol. 63, no. 1, pp. 1–14, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Cai, B. Y. Shin, D. H. Kim et al., “Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils,” Journal of Ethnopharmacology, vol. 138, no. 3, pp. 723–730, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Jang, M. J. Lee, J. M. Lee et al., “Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats,” PLoS ONE, vol. 9, no. 2, Article ID e87623, pp. 1–13, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. J. G. Choi, H. G. Kim, M. C. Kim et al., “Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 414–421, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J. M. Bedford, “Effects of elevated temperature on the epididymis and testis: experimental studies,” in Temperature and Environmental Effects on the Testis, vol. 286 of Advances in Experimental Medicine and Biology, pp. 19–32, Springer, Berlin, Germany, 1991. View at Publisher · View at Google Scholar
  18. R. Mieusset and L. Bujan, “Testicular heating and its possible contributions to male infertility: a review,” International Journal of Andrology, vol. 18, no. 4, pp. 169–184, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Ren, M. S. Medan, M. Ozu, C. Li, G. Watanabe, and K. Taya, “Effects of experimental cryptorchidism on sperm motility and testicular endocrinology in adult male rats,” The Journal of Reproduction and Development, vol. 52, no. 2, pp. 219–228, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Durairajanayagam, A. Agarwal, and C. Ong, “Causes, effects and molecular mechanisms of testicular heat stress,” Reproductive BioMedicine Online, vol. 30, no. 1, pp. 14–27, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Magnan, V. Marin, L. Mély et al., “Venom immunotherapy induces monocyte activation,” Clinical & Experimental Allergy, vol. 31, no. 8, pp. 1303–1309, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. B. P. Setchell, “The effects of heat on the testes of mammals,” Animal Reproduction, vol. 3, no. 2, pp. 81–91, 2006. View at Google Scholar
  23. R. Z. Mahfouz, S. S. du Plessis, N. Aziz, R. Sharma, E. Sabanegh, and A. Agarwal, “Sperm viability, apoptosis, and intracellular reactive oxygen species levels in human spermatozoa before and after induction of oxidative stress,” Fertility and Sterility, vol. 93, no. 3, pp. 814–821, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Gharagozloo and R. J. Aitken, “The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy,” Human Reproduction, vol. 26, no. 7, pp. 1628–1640, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. H.-M. Kim, C.-S. An, K.-Y. Jung, Y.-K. Choo, J.-K. Park, and S.-Y. Nam, “Rehmannia glutinosa inhibits tumour necrosis factor-α and interleukin-1 secretion from mouse astrocytes,” Pharmacological Research, vol. 40, no. 2, pp. 171–176, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. W. S. Park, D. Y. Shin, D. R. Kim, W. M. Yang, M. S. Chang, and S. K. Park, “Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM),” Fertility and Sterility, vol. 88, no. 4, pp. 1000–1002, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. W. M. Yang, S. Y. Park, H.-M. Kim, E. H. Park, S. K. Park, and M. S. Chang, “Effects of Panax ginseng on glial cell-derived neurotrophic factor (GDNF) expression and spermatogenesis in rats,” Phytotherapy Research, vol. 25, no. 2, pp. 308–311, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. Q. Luo, Z. Li, X. Huang, J. Yan, S. Zhang, and Y.-Z. Cai, “Lycium barbarum polysaccharides: protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats,” Life Sciences, vol. 79, no. 7, pp. 613–621, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. S. J. Wu, L. T. Ng, and C. C. Lin, “Antioxidant activities of some common ingredients of traditional Chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos,” Phytotherapy Research, vol. 18, no. 12, pp. 1008–1012, 2004. View at Google Scholar