Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOF/MS

Table 1

TV, PEF, and EF50 in three experimental rat groups ().

Time (weeks)	TV (ml)			PEF (ml/s)			EF50 (ml/s)
	Control	COPD	BYF	Control	COPD	BYF	Control	COPD	BYF
0	2.83 ± 0.56	2.87 ± 0.47	2.93 ± 0.56	14.62 ± 2.96	14.45 ± 2.98	14.82 ± 3.23	1.72 ± 0.22	1.72 ± 0.25	1.71 ± 0.32
4	2.83 ± 0.44	2.51 ± 0.39	2.54 ± 0.44	14.81 ± 2.88	11.15 ± 2.76	11.43 ± 2.96	1.75 ± 0.24	1.47 ± 0.23	1.44 ± 0.29
8	2.84 ± 0.38	2.04 ± 0.51	2.05 ± 0.43	15.09 ± 2.56	10.02 ± 2.54	10.01 ± 2.48	1.76 ± 0.25	1.04 ± 0.27	1.02 ± 0.26
12	2.87 ± 0.43	1.96 ± 0.41	2.12 ± 0.38	15.40 ± 3.02	9.96 ± 2.83	11.34 ± 2.63	1.84 ± 0.24	0.94 ± 0.28	1.09 ± 0.22
16	2.89 ± 0.44	1.92 ± 0.42	2.16 ± 0.35	15.41 ± 2.75	9.91 ± 2.94	11.93 ± 2.83	1.91 ± 0.27	0.95 ± 0.27	1.16 ± 0.28
20	2.93 ± 0.41	1.90 ± 0.46	2.24 ± 0.46	15.41 ± 2.24	9.95 ± 2.79	12.47 ± 2.77	1.94 ± 0.26	1.01 ± 0.27	1.25 ± 0.28
24	2.96 ± 0.31	1.92 ± 0.24	2.30 ± 0.42	15.60 ± 2.57	10.41 ± 1.52	12.47 ± 1.91	1.95 ± 0.23	1.02 ± 0.24	1.32 ± 0.36
28	2.96 ± 0.33	1.97 ± 0.35	2.27 ± 0.33	16.02 ± 1.72	11.06 ± 2.28	14.44 ± 2.71	1.96 ± 0.28	1.07 ± 0.21	1.39 ± 0.32
32	2.97 ± 0.36	1.99 ± 0.34	2.35 ± 0.36	16.50 ± 1.79	11.05 ± 2.01	14.83 ± 1.66	2.06 ± 0.20	1.08 ± 0.24	1.46 ± 0.34