Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOF/MS

Table 2

Biomarkers selected from DMs from two time points (weeks 20 and 32).

	Metabolite	RT (min)	m/z	COPD/control			BYF/COPD
				VIP	t-test	fold	VIP	t-test	Fold
Week 20	2-Methoxyestradiol	5.267	303.1911	1.81	0.001	0.54	2.14	0.004	−0.44
	20-Hydroxy-PGE2	5.9	369.2265	2.08	0	0.63	2.27	0	−0.41
	5-HEPE	8.91	319.2247	2.08	0.001	0.54	1.73	0.03	−0.3
	7-Oxo-11-dodecenoic acid	6.041	213.1483	1.48	0.03	0.35	1.93	0.01	−0.34
	Acetyl-L-leucine	5.12	174.1117	1.56	0.007	0.5	1.99	0.01	−0.48
	Arachidonic acid	9.633	305.2476	1.51	0.038	0.38	1.96	0.01	−0.38
	Eicosapentaenoic acid ethyl ester	7.161	331.2667	1.71	0.005	0.48	1.93	0.01	−0.34
	Linoleic acid	8.913	281.2394	2.04	0	0.52	2.09	0.01	−0.39
	Lipoxin A5	6.676	351.2163	1.9	0.001	0.48	2.09	0.01	−0.38
	N-Acetyl-L-phenylalanine	5.159	208.0964	1.65	0.017	0.45	1.95	0.01	−0.5
	N-Heptanoyl-homoserine lactone	5.026	214.1431	1.59	0.01	0.46	2.03	0.01	−0.45
	N-Nonanoyl-L-homoserine lactone	5.171	242.1745	1.61	0.018	0.49	1.92	0.01	−0.41
	Phenylpyruvic acid	5.08	165.0595	1.37	0.019	−0.68	1.48	0.03	0.6
	α-D-Fucose	5.292	165.0755	1.21	0.024	0.35	1.61	0.03	−0.27
Week 32	Acetylcholine	0.589	146.1169	1.64	0.01	0.43	1.86	0.01	−0.49
	PC (18:1)	11.102	522.3559	1.96	0	−0.25	1.75	0.01	0.38
	Sphinganine	7.917	302.3056	1.57	0.03	−0.42	1.5	0.03	0.52
	Succinic anhydride	0.847	101.0237	1.2	0.04	0.45	1.7	0.01	−0.64
	Arachidonic acid	9.633	305.2476	1.72	0.02	0.49	1.36	0.02	−0.31