Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells

<div>Intracellular reactive oxygen species level of KRG-stimulated HUVECs. HUVECs were pretreated for 1 h with or without 2 <i>μ</i>M auranofin and then incubated with 1 mg/mL KRG. After 18 h of incubation, HUVECs were stimulated with DCF/DA for 55 min, followed by treatment with 500 <i>μ</i>M H<sub>2</sub>O<sub>2</sub> for 5 min. The protective effect of KRG on H<sub>2</sub>O<sub>2</sub>-induced cell death and the abrogation of this effect by the TrxR1 inhibitor, auranofin, were visualized by fluorescence microscopy.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells 