The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain

Figure 1

Intrathecal and oral administration of BE alleviates mechanical allodynia in CIBP. (a) Time course of the development of mechanical allodynia after cancer cell inoculation. Data are expressed as means ± SEM ( versus the sham group). (b) Intrathecal BE alleviates mechanical allodynia in cancer rats. Data are expressed as means ± SEM (, versus cancer + DMSO group). (c) Intrathecal administration of BE has no influence on hind paw withdrawal threshold in naive rats. (d) Oral administration of different doses of BE increased hind paw withdrawal threshold in cancer rats. Data are expressed as means ± SEM ( and versus cancer + DMSO group).

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