Research Article

Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM

Table 3

The CVDs target information.

Gene nameProtein nameDegree

ESR1Estrogen receptor15
ESR2Estrogen receptor beta14
PIM1Proto-oncogene serine/threonine-protein kinase Pim-114
ARAndrogen receptor13
HSP90AA1Heat shock protein HSP 90-alpha12
MAPK14Mitogen-activated protein kinase 1412
NOS2Nitric oxide synthase, inducible12
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform12
PPARGPeroxisome proliferator-activated receptor gamma12
PTGS1Prostaglandin G/H synthase 112
PTGS2Prostaglandin G/H synthase 212
PTPN1Tyrosine-protein phosphatase non-receptor type 112
CDK2Cell division protein kinase 211
GSK3BGlycogen synthase kinase-3 beta11
ALOX12Arachidonate 12-lipoxygenase, 12S-type10
CCNA2Cyclin-A210
ALOX5Arachidonate 5-lipoxygenase9
CA2Carbonic anhydrase 29
MAOAAmine oxidase [flavin-containing] A9
NCOA2Nuclear receptor coactivator 29
CSNK2A1Casein kinase II subunit alpha7
CSNK2BCasein kinase II subunit beta7
CYP19A1Cytochrome P450 19A17
DPP4Dipeptidyl peptidase 47
HSD17B3Estradiol 17-beta-dehydrogenase 37
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform7
CHEK1Serine/threonine-protein kinase Chk16
MAOBAmine oxidase [flavin-containing] B6
CASP3Caspase-35
IMPA2Inositol monophosphatase 25
MIFMacrophage migration inhibitory factor5
PRSS1Trypsin-15
BAXApoptosis regulator BAX4
GLO1Lactoylglutathione lyase4
IMPA1Inositol monophosphatase4
TOP2ADNA topoisomerase 2-alpha4
VCAM1Vascular cell adhesion protein 14
AKR1B1Aldose reductase3
CATCatalase3