Recent Advance in Applications of Proteomics Technologies on Traditional Chinese Medicine Research

Table 2

Proteomics applied in the effective mechanism of TCM treatment in vivo.

Diseases	CHF, CHM, CHM compound, and acupuncture	Targets or signaling pathways	Proteomics methods	References
Cardiocerebrovascular diseases
Arrhythmias	Dingxin recipe	Prohibitin	2DE, MALDI-TOF MS	[50]
Ischemic myocardial injury	Buyang Huanwu decoction	Atrial natriuretic factor	2DE, MALDI-TOF MS	[51]
Cardiovascular disorders	Salvianolic acid B	Integrin α2β	2DE, MALDI-TOF MS/MS	[52]
Cardiovascular disorders	Salvianolic acids	Energy metabolism, lipid metabolism	2DE, MALDI-TOF MS/MS	[53]
Epileptic seizures	Uncaria rhynchophylla	MIF and cyclophilin A	2DE	[54]
Alzheimer’s disease	Yizhijiannao granule	NADH dehydrogenase; iron-sulfur protein 6	2DE, peptide mass fingerprint	[55]
Neurodegenerative diseases	Ginkgo biloba L. extracts	PPAP subunit Band CRMP2	2DE, MALDI-TOF MS	[56]
Cerebrovascular diseases	Tianma	Gnao1, Dctn2, Anxa5, Pacsin1, and Arf3	iTRAQ	[43]
Hepatorenal diseases
Liver cirrhosis	Yiguanjian decoction	Cu/Zn SOD, DJ-1	2DE, MALDI-TOF-TOF MS	[57]
Liver fibrosis	Fuzheng Huayu	Vimentin	2DE/MS	[58]
Liver injury	Yin-Chen-Hao-Tang	Zinc finger protein 407, haptoglobin	RP-HPLC	[59]
Immunological liver injury	Salvia miltiorrhiza	PRDX6	2D-DIGE, MALDI-TOF MS	[60]
Nephropathy	Tanshinone IIA	Oxidative stress	2DE	[61]
Diabetes
Diabetes	Granules	Apolipoprotein E (apoE) and C3	2DE, MALDI-TOF MS/MS	[62]
Type 2 diabetes mellitus	ZiBuPiYin recipe	DRP-2 and PDHE1α	Fluorescence-based DIGE, MS	[63]
Type 2 diabetes mellitus	Tianqijiangtang capsule	Haptoglobin, transthyretin, and prothrombin	2DE, MALDI-TOF-TOF/MS	[64]
Other diseases
Gan stagnancy syndrome	—	TTR, aryl sulfotransferase	2DE, MALDI-TOF MS	[65]
Functional dyspepsia	Wei Kangning	Glutathione S-transferase, pi2	2DE, MALDI-TOF MS	[66]
Spontaneously hypertensive	Formula	HSP-27, annexin-A1, MFN-2, and Rho	2DE, MALDI-TOF MS	[67]
Allergic airway	Xiao-Qing-Long-Tang	Spectrin α2	2DE, MS, MS/MS	[68]
Silicosis	Gymnadenia conopsea	Cathepsin D precursor, peroxiredoxin-1	2DE, MALDI-TOF MS	[69]
Anxiety disorders	Polysaccharides	Beta-synuclein, DJ-1, and peroxiredoxin-2	2DE/MS	[70]
Normal	Acupuncture	NAD-isocitrate dehydrogenase	2DE, MALDI-TOF MS	[71]
Normal	Acupuncture	Local stimulus response, energy metabolism	2DE/MS	[72]
Asthma	Acupuncture	S100A8, RAGE, S100A11, and CC10	2DE, LC-MS/MS	[73]