Identification of a Potential Target of Capsaicin by Computational Target Fishing

Table 1

Top ten potential disease-related targets of capsaicin predicted by PharmMapper.

Rank	PDB ID	Name	Fit score	Disease
1	1BNV	Carbonic anhydrase 2	4.856	Autosomal recessive osteopetrosis type 3
2	1IZ2	Alpha-1-antitrypsin	4.727	Chronic obstructive pulmonary disease
3	1I9Q	Carbonic anhydrase 2	4.581	Autosomal recessive osteopetrosis type 3
4	5P21	GTPase HRas	4.447	Costello syndrome, cancer
5	1B0F	Leukocyte elastase	4.301	Cyclic hematopoiesis
6	2DUX	Aldose reductase	4.228	Diabetes, galactosemia
7	3BYS	Protooncogene tyrosine-protein kinase LCK	4.225	Leukemias
8	1RLB	Transthyretin	4.028	Amyloidosis
9	1I9O	Carbonic anhydrase 2	4.002	Autosomal recessive osteopetrosis type 3
10	1R1H	Neprilysin	3.982	Acute lymphocytic leukemia