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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 1287909, 9 pages
Research Article

PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats

1Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China
2Digestive Disease Department, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China

Received 31 March 2016; Revised 2 June 2016; Accepted 8 June 2016

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2016 Xiaopei Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN). Methods and Results. Diabetic rat model was established by peritoneal injection of streptozotocin (STZ). Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure. We further proved that Tongxinluo upregulates PGC-1α and its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis. Conclusion. Our study indicates that the protective effect of Txl in diabetic neuropathy may be attributed to the induction of PGC-1α and its downstream targets. This finding may further illustrate the pleiotropic effect of the medicine.