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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 1287909, 9 pages
http://dx.doi.org/10.1155/2016/1287909
Research Article

PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats

1Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China
2Digestive Disease Department, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China

Received 31 March 2016; Revised 2 June 2016; Accepted 8 June 2016

Academic Editor: Kuttulebbai N. S. Sirajudeen

Copyright © 2016 Xiaopei Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. E. Argoff, B. E. Cole, D. A. Fishbain, and G. A. Irving, “Diabetic peripheral neuropathic pain: clinical and quality-of-life issues,” Mayo Clinic Proceedings, vol. 81, no. 4, supplement, pp. S3–S11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. X.-P. Cui, B.-Y. Li, H.-Q. Gao, N. Wei, W.-L. Wang, and M. Lu, “Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats,” Journal of Nutritional Science and Vitaminology, vol. 54, no. 4, pp. 321–328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. S. Estrella, R. N. Nelson, B. K. Sturges et al., “Endoneurial microvascular pathology in feline diabetic neuropathy,” Microvascular Research, vol. 75, no. 3, pp. 403–410, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. The Diabetes Control and Complications Trial Research Group, “The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus,” The New England Journal of Medicine, vol. 329, no. 14, pp. 977–986, 1993. View at Publisher · View at Google Scholar
  5. P. Fernyhough and M. Jonathan, “Mechanisms of disease: mitochondrial dysfunction in sensory neuropathy and other complications in diabetes,” Handbook of Clinical Neurology, vol. 126, pp. 353–377, 2014. View at Publisher · View at Google Scholar
  6. E. Akude, E. Zherebitskaya, S. K. R. Chowdhury, D. R. Smith, R. T. Dobrowsky, and P. Fernyhough, “Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats,” Diabetes, vol. 60, no. 1, pp. 288–297, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Wu, Q. Wang, F. Guo et al., “Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats,” Molecular and Cellular Endocrinology, vol. 413, pp. 1–12, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. M. E. Patti, A. J. Butte, S. Crunkhorn et al., “Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8466–8471, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. H.-T. Zhang, Z.-H. Jia, J. Zhang et al., “No-reflow protection and long-term efficacy for acute myocardial infarction with Tongxinluo: a randomized double-blind placebo-controlled multicenter clinical trial (ENLEAT trial),” Chinese Medical Journal, vol. 123, no. 20, pp. 2858–2864, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. C.-Y. Zheng, L.-L. Song, J.-K. Wen et al., “Tongxinluo (TXL), a traditional chinese medicinal compound, improves endothelial function after chronic hypoxia both in vivo and in vitro,” Journal of Cardiovascular Pharmacology, vol. 65, no. 6, pp. 579–586, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Zhang, T. Pan, X. Zhong, and C. Cheng, “Tongxinluo prevents endothelial dysfunction induced by homocysteine thiolactone in vivo via suppression of oxidative stress,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 929012, 9 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Wang, Q. Yang, W.-W. Bai et al., “Tongxinluo protects against pressure overload-induced heart failure in mice involving VEGF/Akt/eNOS pathway activation,” PLoS ONE, vol. 9, no. 6, Article ID e98047, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-Y. Wang, Y.-B. Gao, N. Zhang et al., “Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy,” American Journal of Physiology—Renal Physiology, vol. 306, no. 5, pp. F486–F495, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Zhao and X.-L. Zhang, “Effect of tongxinluo capsule on plasma endothelin in patients with diabetic nephropathy,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 25, no. 2, pp. 131–133, 2005. View at Google Scholar · View at Scopus
  15. F. Cui, D. Zou, Y. Gao et al., “Effect of tongxinluo on nephrin expression via inhibition of notch1/snail pathway in diabetic rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 424193, 11 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Li, J. Zhang, W. Zhao et al., “Effect of Tongxinluo on nerve regeneration in mice with diabetic peripheral neuropathy,” Cellular and Molecular Biology, vol. 61, no. 5, pp. 103–107, 2015. View at Google Scholar
  17. C. Wang, H.-X. Zhang, H.-Y. Xing, and X. Wang, “Effects of Tongxinluo capsule on sciatic nerve apoptosis in spontaneous type II diabetic KK/Upj-Ay mice and mechanism research,” Zhongguo Zhong Yao Za Zhi, vol. 40, no. 7, pp. 1396–1399, 2015. View at Google Scholar · View at Scopus
  18. L. Zhang, Y. Liu, X. T. Lu et al., “Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 297, no. 6, pp. H2004–H2014, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Google Scholar
  20. O. J. Freeman, R. D. Unwin, A. W. Dowsey et al., “Metabolic dysfunction is restricted to the sciatic nerve in experimental diabetic neuropathy,” Diabetes, vol. 65, no. 1, pp. 228–238, 2016. View at Publisher · View at Google Scholar
  21. R. Ni, D. Zheng, S. Xiong et al., “Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type-1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy,” Diabetes, vol. 65, no. 1, pp. 255–268, 2016. View at Publisher · View at Google Scholar
  22. Z. Wu, P. Puigserver, U. Andersson et al., “Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1,” Cell, vol. 98, no. 1, pp. 115–124, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. H.-Q. Wang, J.-J. Zou, X.-H. Zhou, L.-N. Ji, and Z.-M. Liu, “Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats,” Chinese Medical Journal, vol. 125, no. 20, pp. 3675–3680, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Kumar, T. Raman, M. M. Swain, R. Mishra, and A. Pal, “Hyperglycemia-induced oxidative-nitrosative stress induces inflammation and neurodegeneration via augmented tuberous sclerosis complex-2 (TSC-2) activation in neuronal cells,” Molecular Neurobiology, 2016. View at Publisher · View at Google Scholar · View at Scopus