<i>Bothrops jararaca</i> and<i> Bothrops erythromelas</i> Snake Venoms Promote Cell Cycle Arrest and Induce Apoptosis via the Mitochondrial Depolarization of Cervical Cancer Cells

<div><i>Bothrops</i> snake venoms induce apoptosis SiHa in HeLa cells (48 h). Cervical cancer cells were treated with BJ and BE 50 (<i>μ</i>g/mL), with untreated cells compared and analyzed by annexin V-FITC/PI staining. Frames were divided into four quadrants: cells stained with annexin V and PI were classified as necrotic (Q1; annexin V−/PI+), late apoptotic (Q2; annexin V+/PI+), early apoptotic (Q3; annexin V+/PI−), or intact (Q4; annexin V−/PI−). Untreated cells (NC), Cisplatin (CDDP),<i> B. jararaca</i> (BJ), and<i> B. erythromelas</i> (BE).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: <i>Bothrops jararaca</i> and<i> Bothrops erythromelas</i> Snake Venoms Promote Cell Cycle Arrest and Induce Apoptosis via the Mitochondrial Depolarization of Cervical Cancer Cells 

Figure 3 | Bothrops jararaca and Bothrops erythromelas Snake Venoms Promote Cell Cycle Arrest and Induce Apoptosis via the Mitochondrial Depolarization of Cervical Cancer Cells 