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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 1698379, 9 pages
Research Article

Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke

1Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China
2The Academy of Integrative Medicine of Fudan University, Shanghai 20040, China

Received 29 February 2016; Revised 9 August 2016; Accepted 23 August 2016

Academic Editor: Salvatore Chirumbolo

Copyright © 2016 Jinpei Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.