Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke

Figure 4

Regulation of mRNA expressions of antioxidant enzymes including HO-1, γ-GCS, and SOD via an Nrf2 dependent mechanism. PF of all three dosages significantly increased the total amount of mRNA expression of antioxidant enzymes by means of upregulating ATF-4 (a) and Nrf2 (b) mRNA expressions as well as HO-1 (c), SOD (d), and γ-GCS (e) in the lung tissue. , , compared with the Normal Control group. , , compared with the COPD group. , , compared with Budesonide group.

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