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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 1713897, 13 pages
Research Article

Clinical Effect and Mechanism of Yisui Shengxue Granules in Thalassemia Patients with Mild, Moderate, or Severe Anemia

1Laboratory of Molecular Biology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
2Department of Hematology, 303rd Hospital of PLA, Nanning 530021, China

Received 16 August 2015; Revised 2 November 2015; Accepted 1 December 2015

Academic Editor: Ilaria Lampronti

Copyright © 2016 Yan-Ling Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Yisui Shengxue granules, which is a Chinese traditional medicine, can increase hemoglobin, red blood cells, and Ret of thalassemia patients with mild, moderate, and severe anemia and thus relieve clinical anemia symptoms. Studies on mechanism found that Yisui Shengxue granules can increase the proliferation ability of hematopoietic stem cells. Emodin promoted colony forming of hematopoietic stem cells. Yisui Shengxue granules can increase the activity of GSH-PX in bone marrow blood and decreased the severity of inclusion bodies on the cytomembrane of RBCs. YSSXG attenuated anemia symptoms in patients with thalassemia mostly by increasing the proliferation of hematopoietic stem cells and decreasing the hemolysis of RBCs.