Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 1739760, 13 pages
http://dx.doi.org/10.1155/2016/1739760
Research Article

Hataedock Treatment Has Preventive Therapeutic Effects in Atopic Dermatitis-Induced NC/Nga Mice under High-Fat Diet Conditions

1Department of Korean Pediatrics, Hospital of Korean Medicine, Pusan National University, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea
2Research Institute for Korean Medicine, Pusan National University, 49 Pusandaehak-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea
3Department of Anatomy, College of Korean Medicine, Dongguk University, Seokjang-dong, Gyeongju-si, Gyeongsangbuk-do 38066, Republic of Korea
4Department of Korean Pediatrics, School of Korean Medicine, Pusan National University, 49 Pusandaehak-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea

Received 26 February 2016; Revised 25 April 2016; Accepted 4 May 2016

Academic Editor: Arpita Basu

Copyright © 2016 Ho-Yeol Cha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Behniafard, M. Gharagozlou, E. Farhadi et al., “TNF-alpha single nucleotide polymorphisms in atopic dermatitis,” European Cytokine Network, vol. 23, no. 4, pp. 163–165, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Kawakami, T. Ando, M. Kimura, B. S. Wilson, and Y. Kawakami, “Mast cells in atopic dermatitis,” Current Opinion in Immunology, vol. 21, no. 6, pp. 666–678, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. K. C. Barnes, “An update on the genetics of atopic dermatitis: scratching the surface in 2009,” Journal of Allergy and Clinical Immunology, vol. 125, no. 1–3, pp. 16.e11–29.e11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Danby and M. J. Cork, “A new understanding of atopic dermatitis: the role of epidermal barrier dysfunction and subclinical inflammation,” Journal of Clinical Dermatology, vol. 1, pp. 33–46, 2012. View at Google Scholar
  5. P. M. Elias and M. Schmuth, “Abnormal skin barrier in the etiopathogenesis of atopic dermatitis,” Current Opinion in Allergy and Clinical Immunology, vol. 9, no. 5, pp. 437–446, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Y. M. Leung, M. Boguniewicz, M. D. Howell, I. Nomura, and Q. A. Hamid, “New insights into atopic dermatitis,” The Journal of Clinical Investigation, vol. 113, no. 5, pp. 651–657, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Yabuhara, C. Macaubas, S. L. Prescott et al., “TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood,” Clinical and Experimental Allergy, vol. 27, no. 11, pp. 1261–1269, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. F. I. Smillie, A. J. Elderfield, F. Patel et al., “Lymphoproliferative responses in cord blood and at one year: no evidence for the effect of in utero exposure to dust mite allergens,” Clinical and Experimental Allergy, vol. 31, no. 8, pp. 1194–1204, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Löffler, J. U. N. Aramaki, and I. Effendy, “The influence of body mass index on skin susceptibility to sodium lauryl sulphate,” Skin Research and Technology, vol. 8, no. 1, pp. 19–22, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Nino, A. Franzese, N. Ruggiero Perrino, and N. Balato, “The effect of obesity on skin disease and epidermal permeability barrier status in children,” Pediatric Dermatology, vol. 29, no. 5, pp. 567–570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Zhang and J. I. Silverberg, “Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis,” Journal of the American Academy of Dermatology, vol. 72, no. 4, pp. 606–616.e4, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. S. M. O'Donovan, J. O'B Hourihane, D. M. Murray et al., “Neonatal adiposity increases the risk of atopic dermatitis during the first year of life,” Journal of Allergy and Clinical Immunology, vol. 137, no. 1, pp. 108–117, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. H. W. Jeong and H. S. Kim, “Oriental medical approach on the allergic disease,” Korean Journal of Oriental Physiology and Pathology, vol. 16, no. 5, pp. 831–839, 2002. View at Google Scholar
  14. A. Baroni, E. Ruocco, T. Russo et al., “The use of traditional Chinese medicine in some dermatologic diseases: part II—autoimmune bullous disorders and lichen planus,” Skinmed, vol. 13, no. 3, pp. 195–203, 2015. View at Google Scholar · View at Scopus
  15. H. Y. Cha, S. H. Ahn, A. R. Jeong, J. H. Cheon, S. Y. Park, and K. B. Kim, “The effects of hataedock on 2,4-dinitrofluorobenzene induced atopic dermatitis like skin lesion in NC/Nga mice,” The Journal of Korean Oriental Pediatrics, vol. 29, no. 4, pp. 97–107, 2015. View at Publisher · View at Google Scholar
  16. H. Y. Cha, S. H. Ahn, A. R. Jeong et al., “Anti-inflammatory effects of hataedock extracted from coptidis rhizoma and glycyrrhiza uralensis on atopic dermatitis-like skin lesions of NC/Nga mouse,” Journal of Korean Oriental Internal Medicine, vol. 36, no. 4, pp. 486–497, 2015. View at Google Scholar
  17. B. Pang, X.-T. Yu, Q. Zhou et al., “Effect of Rhizoma coptidis (Huang Lian) on treating diabetes mellitus,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 921416, 10 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Wang, W. Mu, H. Shang, J. Lin, and X. Lei, “The antihyperglycemic effects of rhizoma coptidis and mechanism of actions: a review of systematic reviews and pharmacological research,” BioMed Research International, vol. 2014, Article ID 798093, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Xie, D. Gu, J. Li, K. Cui, and Y. Zhang, “Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice,” PLoS ONE, vol. 6, no. 9, Article ID e24520, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Jayaprakasam, S. Doddaga, R. Wang, D. Holmes, J. Goldfarb, and X.-M. Li, “Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro,” Journal of Agricultural and Food Chemistry, vol. 57, no. 3, pp. 820–825, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Fu, J. Chen, Y.-J. Li, Y.-F. Zheng, and P. Li, “Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice,” Food Chemistry, vol. 141, no. 2, pp. 1063–1071, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. H. J. Kim, J.-Y. Seo, H.-J. Suh, S. S. Lim, and J.-S. Kim, “Antioxidant activities of licorice-derived prenylflavonoids,” Nutrition Research and Practice, vol. 6, no. 6, pp. 491–498, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. D. E. Cohen and N. Heidary, “Treatment of irritant and allergic contact dermatitis,” Dermatologic Therapy, vol. 17, no. 4, pp. 334–340, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Bieber, “Atopic dermatitis,” Annals of Dermatology, vol. 22, no. 2, pp. 125–137, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. K. E. Wellen and G. S. Hotamisligil, “Inflammation, stress, and diabetes,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1111–1119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. U. Hoppu, M. Kalliomaki, and E. Isolauri, “Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant,” European Journal of Clinical Nutrition, vol. 54, no. 9, pp. 702–705, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. K.-H. Kim and S.-Y. Choung, “Oral administration of vaccinium uliginosum L. extract alleviates dncb-induced atopic dermatitis in NC/Nga mice,” Journal of Medicinal Food, vol. 17, no. 12, pp. 1350–1360, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Ha, H. Lee, C. S. Seo et al., “Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice,” BMC Complementary and Alternative Medicine, vol. 14, article 100, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. M.-C. Kim, C.-H. Lee, and T.-H. Yook, “Effects of anti-inflammatory and rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice,” Journal of Acupuncture and Meridian Studies, vol. 6, no. 2, pp. 98–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. H.-S. Lim, C.-S. Seo, H. Ha et al., “Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in NC/Nga mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 705167, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Dubois, N. Deruytter, B. Adams et al., “Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life,” The Journal of Immunology, vol. 185, no. 2, pp. 884–891, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. E. B. Brandt and U. Sivaprasad, “Th2 cytokines and atopic dermatitis,” Journal of Clinical & Cellular Immunology, vol. 2, no. 3, p. 110, 2011. View at Publisher · View at Google Scholar
  33. G. Herberth, J. Heinrich, S. Röder et al., “Reduced IFN-γ- and enhanced IL-4-producing CD4+ cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life,” Pediatric Allergy and Immunology, vol. 21, no. 1, part I, pp. 5–13, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Levin, S. F. Friedlander, and J. Q. Del Rosso, “Atopic dermatitis and the stratum corneum: part 1: the role of filaggrin in the stratum corneum barrier and atopic skin,” Journal of Clinical and Aesthetic Dermatology, vol. 6, no. 10, pp. 16–22, 2013. View at Google Scholar · View at Scopus
  35. H. Kim, R. Zamel, X.-H. Bai, and M. Liu, “PKC activation induces inflammatory response and cell death in human bronchial epithelial cells,” PLoS ONE, vol. 8, no. 5, Article ID e64182, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. A. C. Newton, “Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm,” Biochemical Journal, vol. 370, no. 2, pp. 361–371, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. C. J. Delvecchio and J. P. Capone, “Protein kinase C α modulates liver X receptor α transactivation,” Journal of Endocrinology, vol. 197, no. 1, pp. 121–130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Nomiyama and D. Bruemmer, “Liver X receptors as therapeutic targets in metabolism and atherosclerosis,” Current Atherosclerosis Reports, vol. 10, no. 1, pp. 88–95, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. L. G. Kömüves, K. Hanley, Y. Jiang, P. M. Elias, M. L. Williams, and K. R. Feingold, “Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development,” Journal of Investigative Dermatology, vol. 111, no. 3, pp. 429–433, 1998. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Hanley, D. C. Ng, S. S. He et al., “Oxysterols induce differentiation in human keratinocytes and increase AP-1-dependent involucrin transcription,” Journal of Investigative Dermatology, vol. 114, no. 3, pp. 545–553, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. Hatano, M.-Q. Man, Y. Uchida et al., “Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators,” Journal of Allergy and Clinical Immunology, vol. 125, no. 1, pp. 160–169.e5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. L. G. Kömüves, M. Schmuth, A. J. Fowler et al., “Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-β in murine epidermis,” Journal of Investigative Dermatology, vol. 118, no. 1, pp. 25–34, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. H. J. Gould, B. J. Sutton, A. J. Beavil et al., “The biology of IgE and the basis of allergic disease,” Annual Review of Immunology, vol. 21, pp. 579–628, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. S. J. Galli and M. Tsai, “IgE and mast cells in allergic disease,” Nature Medicine, vol. 18, no. 5, pp. 693–704, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Naukkarinen, I. Harvima, K. Paukkonen, M.-L. Aalto, and M. Horsmanheimo, “Immunohistochemical analysis of sensory nerves and neuropeptides, and their contacts with mast cells in developing and mature psoriatic lesions,” Archives of Dermatological Research, vol. 285, no. 6, pp. 341–346, 1993. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Suzuki, S. Miura, Y. Y. Liu, M. Tsuchiya, and H. Ishii, “Substance P induces degranulation of mast cells and leukocyte adhesion to venular endothelium,” Peptides, vol. 16, no. 8, pp. 1447–1452, 1995. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Pavlovic, M. Daniltchenko, D. J. Tobin et al., “Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice,” Journal of Investigative Dermatology, vol. 128, no. 2, pp. 434–446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. C.-F. Wahlgren, “Itch and atopic dermatitis: an overview,” Journal of Dermatology, vol. 26, no. 11, pp. 770–779, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. N. Kanbe, A. Tanaka, M. Kanbe, A. Itakura, M. Kurosawa, and H. Matsuda, “Human mast cells produce matrix metalloproteinase 9,” European Journal of Immunology, vol. 29, no. 8, pp. 2645–2649, 1999. View at Publisher · View at Google Scholar · View at Scopus
  50. A. C. A. Devillers, A. W. Van Toorenenbergen, G. J. Klein Heerenbrink, P. G. H. Mulder, and A. P. Oranje, “Elevated levels of plasma matrix metalloproteinase-9 in patients with atopic dermatitis: a pilot study,” Clinical and Experimental Dermatology, vol. 32, no. 3, pp. 311–313, 2007. View at Publisher · View at Google Scholar · View at Scopus
  51. M. O. Danso, V. van Drongelen, A. Mulder et al., “TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents,” Journal of Investigative Dermatology, vol. 134, no. 7, pp. 1941–1950, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Tanaka, S. Muto, K. Jung, A. Itai, and H. Matsuda, “Topical application with a new NF-κB inhibitor improves atopic dermatitis in NC/NgaTnd mice,” Journal of Investigative Dermatology, vol. 127, no. 4, pp. 855–863, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Blaecke, Y. Delneste, N. Herbault et al., “Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry,” Cytometry, vol. 48, no. 2, pp. 71–79, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Viatour, M.-P. Merville, V. Bours, and A. Chariot, “Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation,” Trends in Biochemical Sciences, vol. 30, no. 1, pp. 43–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. K. Orita, K. Hiramoto, H. Kobayashi, M. Ishii, A. Sekiyama, and M. Inoue, “Inducible nitric oxide synthase (iNOS) and α-melanocyte-stimulating hormones of iNOS origin play important roles in the allergic reactions of atopic dermatitis in mice,” Experimental Dermatology, vol. 20, no. 11, pp. 911–914, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. D. Laouini, A. Elkhal, A. Yalcindag, S. Kawamoto, H. Oettgen, and R. S. Geha, “COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization,” Journal of Allergy and Clinical Immunology, vol. 116, no. 2, pp. 390–396, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. L. Leifeld, M. Fielenbach, F.-L. Dumoulin, N. Speidel, T. Sauerbruch, and U. Spengler, “Inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) expression in fulminant hepatic failure,” Journal of Hepatology, vol. 37, no. 5, pp. 613–619, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Taniuchi, T. Kojima, K. Hara Mt et al., “Increased serum nitrate levels in infants with atopic dermatitis,” Allergy, vol. 56, no. 7, pp. 693–695, 2001. View at Publisher · View at Google Scholar · View at Scopus
  59. K. Fogh, T. Herlin, and K. Kragballe, “Eicosanoids in skin of patients with atopic dermatitis: prostaglandin E2 and leukotriene B4 are present in biologically active concentrations,” The Journal of Allergy and Clinical Immunology, vol. 83, no. 2, pp. 450–455, 1989. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Grigaitiene, I. Marciukaitiene, A. Blaziene, and A. Chomiciene, “Study of apoptosis in normal skin tissues,” Medicina (Kaunas, Lithuania), vol. 43, no. 4, pp. 301–305, 2007. View at Google Scholar · View at Scopus
  61. K. L. Rock and H. Kono, “The inflammatory response to cell death,” Annual Review of Pathology: Mechanisms of Disease, vol. 3, pp. 99–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. A. Trautmann, M. Akdis, K. Blaser, and C. A. Akdis, “Role of dysregulated apoptosis in atopic dermatitis,” Apoptosis, vol. 5, no. 5, pp. 425–429, 2000. View at Publisher · View at Google Scholar · View at Scopus
  63. K. W. Yip and J. C. Reed, “Bcl-2 family proteins and cancer,” Oncogene, vol. 27, no. 50, pp. 6398–6406, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. Y. Tsujimoto, “Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?” Genes to Cells, vol. 3, no. 11, pp. 697–707, 1998. View at Publisher · View at Google Scholar · View at Scopus
  65. A. G. Porter and R. U. Jänicke, “Emerging roles of caspase-3 in apoptosis,” Cell Death and Differentiation, vol. 6, no. 2, pp. 99–104, 1999. View at Publisher · View at Google Scholar · View at Scopus
  66. T. Rudel, “Caspase inhibitors in prevention of apoptosis,” Herz, vol. 24, no. 3, pp. 236–241, 1999. View at Publisher · View at Google Scholar · View at Scopus
  67. D. G. Kirsch, A. Doseff, B. N. Chau et al., “Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c,” Journal of Biological Chemistry, vol. 274, no. 30, pp. 21155–21161, 1999. View at Publisher · View at Google Scholar · View at Scopus