Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease

Figure 3

Oral treatment of herbal formula B401 effectively ameliorates cognitive dysfunction in 3× Tg-AD mice. (a) Morris water maze in 3× Tg-AD mice and their control (non-AD mice). (A) Representative path tracing experiments in 3× Tg-AD mice and their control (non-AD mice) in which mice were started from quadrant A and target in quadrant C. (B) Oral B401 treatment significantly reduces escape latency to reach the platform in 3× Tg-AD mice over 8 test days. (C) oral B401 treatment significantly increases the time spent in the target quadrant during the probe test in 3× Tg-AD mice. (b) Novel object recognition task in 3× Tg-AD mice and their control (non-AD mice). The discrimination index was calculated as percentage ratio of . : familiar object. : novel object. (c) Spontaneous alternation behavior Y-maze test in 3× Tg-AD mice and their control (non-AD mice). Alternation (%) = [(Number of alternations)/(Total arm entries − 2)] × 100. The number of mice was eight for each group. Values are mean ± SEM (; , one-way ANOVA followed by a Student- Newman-Keuls multiple comparisons post test).

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