Membrane Stabilization and Detoxification of Acetaminophen-Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction of Zea mays L. (Poaceae), Stigma maydis
Table 5
Effect of Zea mays, Stigma maydis ethyl acetate fraction on the levels of nonenzymic antioxidant system, protein-oxidized products, and fragmented DNA of acetaminophen-treated rats (, mean ± SEM).
Treatment
GSH (X)
GSSG (X)
GSH/GSSG
PC (X)
AOPP (Y)
F/DNA (%)
Sterile placebo (control)
35.11 ± 1.35
0.20 ± 0.01
175.55 ± 0.20
3.72 ± 0.25
195.98 ± 1.99
10.12 ± 0.10
APAP treatment
7.56 ± 1.09
1.99 ± 0.02
3.80 ± 0.08
15.12 ± 0.22
501.23 ± 1.59
65.15 ± 0.19
200 mg/kg b.w. CSEAF
25.02 ± 1.08
0.12 ± 0.03
208.50 ± 0.32
3.66 ± 0.40
190.23 ± 1.45
11.75 ± 0.14
100 mg/kg b.w. CSEAF, then APAP
30.19 ± 1.11
0.21 ± 0.02
143.29 ± 0.19
8.00 ± 0.25
275.99 ± 1.40
30.16 ± 0.15
200 mg/kg b.w. CSEAF, then APAP
31.01 ± 1.06
0.16 ± 0.03
193.81 ± 0.15
4.67 ± 0.32
193.01 ± 1.34
12.01 ± 0.18
200 mg/kg b.w. vitamin C, then APAP
36.11 ± 1.32
0.19 ± 0.02
190.05 ± 0.17
3.89 ± 0.25
200.45 ± 1.29
11.21 ± 0.19
APAP, then 100 mg/kg b.w. CSEAF
15.99 ± 1.11
0.22 ± 0.01
72.68 ± 0.15
9.04 ± 0.22
287.32 ± 1.88
31.00 ± 0.10
APAP, then 200 mg/kg b.w. CSEAF
16.21 ± 1.00
0.19 ± 0.05
85.32 ± 0.09
9.14 ± 0.35
203.19 ± 1.25
12.09 ± 0.11
APAP, then 200 mg/kg b.w. vitamin C
15.15 ± 1.72
0.19 ± 0.05
79.74 ± 0.10
8.01 ± 0.29
212.34 ± 1.67
12.13 ± 0.15
Values with different superscripts for each parameter are significantly different (). APAP: acetaminophen, CSEAF: corn silk ethyl acetate fraction, GSH: reduced glutathione, GSSG: peroxidized glutathione, PC: protein carbonyl, AOPP: advanced oxidation protein product, F/DNA: fragmented DNA, X: nmol mg protein−1, and Y: µmol mg protein−1.
