Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

Figure 3

The heatmap compares the five major protein families that were annotated based on the enriched targets in each cluster, which were normalized. The more saturated colour across clusters represents the more significant protein family. GPCR and protein kinase are observed to be significant protein families in almost all clusters. It appears that all the protein families are heavily implicated in the biological processes such as cell regulation, sensory system, and steroid metabolism. The significant cluster for a particular protein family can be suggested to be further explored for a disease with the known protein family such as protein kinase in cancer.