Evidence-Based Complementary and Alternative Medicine

Research Article

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

Table 2

The top three enriched targets in clusters VII, X, and XII. It can be seen that, in many cases, the top three enriched targets are implicated in immunomodulation. Estimation Score = 0, for all top three enriched targets.


	TCM therapeutic action class	TCM therapeutic action subclass	Top three enriched targets	Target function reported by literatures	Average Score

Cluster X	Wind-dampness dispelling	Bone (sinew) strengthening	DNA topoisomerase 1	Cancer	0.0144
			Sodium/glucose cotransporter 1	Glucose homeostasis	0.0342
			Steryl-sulfatase	Immunomodulation	0.0370
	Tonifying and replenishing	Qi tonifying	Tyrosine-protein phosphatase nonreceptor type 2	Immunomodulation	0.0174
			Sodium/glucose cotransporter 2	Glucose homeostasis	0.0282
			Sodium/glucose cotransporter 1	Glucose homeostasis	0.0321
	Cough suppressing and panting-calming	Clearing and heat phlegm resolving	Tyrosine-protein phosphatase nonreceptor type 2	Immunomodulation	0.0112
			DNA topoisomerase 1	Cancer	0.0236
			Testosterone 17-beta-dehydrogenase 3	Reproduction system	0.0341
	Tranquilizing	Heat nourishing tranquilizing	Peptidyl-prolyl cis-trans isomerase FKBP1A	Immunomodulation	0.0077
			Tyrosine-protein phosphatase nonreceptor type 2	Immunomodulation	0.0167
			Glutamate carboxypeptidase 2	CNS	0.0209

Cluster VII	Heat-clearing medicinal	Heat-clearing and blood cooling	Protein kinase C beta type	Immunomodulation	0.0100
			DNA topoisomerase 1	Cancer	0.0123
			Sodium/glucose cotransporter 2	Glucose homeostasis	0.0137
	Hemostatic medicinal	Stasis resolving hemostatic	Tyrosine-protein phosphatase nonreceptor type 2	Immunomodulation	0.0089
			Protein kinase C eta type	Immunomodulation	0.0182
			Protein kinase C gamma type	Immunomodulation	0.0209
	Tonifying and replenishing	Blood tonifying	Tyrosine-protein phosphatase nonreceptor type 2	Immunomodulation	0.0140
			Protein kinase C beta type	Immunomodulation	0.0230
			Protein kinase C eta type	Immunomodulation	0.0240

Cluster XII	Parasite destroying, dampness eliminating, and itchiness relieving		Dihydrofolate reductase	Cancer, bacterial infection	0.0532
			DNA-dependent protein kinase catalytic subunit	Cancer	0.0644
			Tumour necrosis factor	Cancer, bacterial infection	0.0687