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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 2146204, 12 pages
http://dx.doi.org/10.1155/2016/2146204
Review Article

Efficacy and Safety of Chinese Medicinal Herbs for the Treatment of Hyperuricemia: A Systematic Review and Meta-Analysis

1Subsidiary Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China
2College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China
3Orthopaedics and Traumatology College, Fujian University of Traditional Chinese Medicine, Fuzhou, China

Received 26 June 2016; Revised 15 August 2016; Accepted 28 August 2016

Academic Editor: Young-Su Yi

Copyright © 2016 Jianping Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Chinese medicinal herbs may be useful for the treatment of hyperuricemia, but there has been no systematic assessment of their efficacy and safety. Objectives. To systematically assess the efficacy and safety of Chinese medicinal herbs for the treatment of hyperuricemia. Methods. Six electronic databases were searched from their inception to December 2015. Randomized controlled clinical trials (RCTs) were included. Cochrane criteria were applied to assess the risk of bias. Data analysis was performed using RevMan software version 5.2. Results. Eleven RCTs with 838 patients were included. There was no significant difference in serum uric acid between Chinese medicinal herbs and traditional Western medicine (SME: 0.19, 95% CI: −0.04 to 0.43; ). In terms of overall efficacy, the Chinese medicinal herbs were significantly superior to Western medicine (RR: 1.11; 95% CI: 1.04 to 1.17; ). The Chinese medicinal herbs were better than Western medicine in reducing the adverse reactions (RR: 0.30; 95% CI: 0.15 to 0.62; ). And all these funnel plots showed unlikelihood of publishing bias. Conclusions. The results indicate that Chinese medicinal herbs may have greater overall efficacy with fewer adverse drug reactions, although the evidence is weak owing to the low methodological quality and the small number of the included trials.