| | Author, year | The overall efficacy (EG▲)
C/M/E/I☆ | The overall efficacy (CG▲)
C/M/E/I☆ | The overall efficacy (RR, 95% CI); value | SUA● (umol/L) (EG: B/A■) | SUA (umol/L) (CG:B/A) | SUA (SMD, 95% CI); value | Adverse reactions (EG) | Adverse reactions (CG) | Adverse reactions (RR, 95% CI) |
| | Zhou, 2007 [13] | 16/0/17/3☆ | 5/0/10/13 | 1.71 (1.20, 2.45); | N/A★ | N/A | N/A | N/A | N/A | N/A | | Chen, 2008 [14] | N/A | N/A | N/A | 488.91 ± 70.51/316.12 ± 86.25 | 489.61 ± 69.89/301.93 ± 93.77 | 0.16 (−0.30, 0.61); | N/A | N/A | N/A | | Yu, 2012 [15] | 0/12/36/2 | 0/8/33/9 | 1.17 (1.02, 1.35); | 585.83 ± 93.93/319.13 ± 87.63 | 584.94 ± 90.29/358.86 ± 88.53 | −0.45 (−0.84, −0.05); | Diarrhea: 2 | Liver damaged: 2 | 1.00 (0.15, 6.82) | | Tan et al., 2013 [16] | 0/15/14/1 | 0/17/11/2 | 1.04 (0.92, 1.16); | 546.69 ± 51.45/354.72 ± 27.29 | 550.33 ± 45.99/352.14 ± 25.67 | 0.10 (−0.41, 0.60); | Liver damaged: 1, kidney damaged: 1, leucopenia: 0, nausea: 2, and acute arthritis: 0 | Liver damaged: 2, kidney damaged: 1, leucopenia: 1, nausea: 1, and acute arthritis: 2 | 0.57 (0.19, 1.75) | | Li, 2007 [17] | 0/21/14/5 | 0/19/13/8 | 1.09 (0.90, 1.33); : N/A | 524.43 ± 43.14/410.17 ± 60.25 | 528.50 ± 45.72/413.46 ± 55.84 | −0.06 (−0.49, 0.38); | Diarrhea: 2 | Liver damaged: 10, leucopenia: 8, and itchy skin: 1 | 0.11 (0.03, 0.42) | | Xiang et al., 2014 [18] | N/A | N/A | N/A | 451.33 ± 98.55/370.45 ± 91.45 | 442.64 ± 97.46/357.35 ± 98.57 | 0.14 (−0.25, 0.53); | None | Itchy skin: 1 | 0.33 (0.15, 0.65) | | Cai et al., 2014 [19] | 11/0/35/4 | 6/0/32/12 | 1.21 (1.02, 1.44); | 517.2 ± 86.33/328.8 ± 87.56 | 514.5 ± 90.29/359.4 ± 88.63 | −0.34 (−0.74, 0.05); | N/A | N/A | N/A | | Zhou et al., 2010 [20] | 0/14/12/4 | 0/8/12/10 | 1.30 (0.97, 1.74); | 521.84 ± 75.32/290.45 ± 74.76 | 514.43 ± 83.35/323.44 ± 71.98 | −0.44 (−0.96, 0.07); | N/A | N/A | N/A | | Hong and Shen, 2011 [21] | 29/0/6/1 | 7/0/8/3 | 1.17 (0.94, 1.44); | 546.0 ± 78.1/353.0 ± 122.6 | 533.0 ± 62.3/425.0 ± 169.1 | −0.51 (−1.08, 0.07); | None | Liver damaged: 3, abnormal changes of blood cells: 2, and acute episode of gout: 1 | 0.04 (0.00, 0.66) | | Hu, 2006 [22] | 0/20/16/4 | 0/22/12/6 | 1.06 (0.90, 1.25); | 575.38 ± 52.62/389.30 ± 13.07 | 568.48 ± 53.10/398.30 ± 610.08 | −0.20 (−0.64, 0.24); | None | Nausea: 1 and itchy skin: 1 | 0.2 (0.01, 4.04) | | Zhang et al., 2011 [23] | 0/14/10/4 | 0/18/8/2 | 0.92 (0.77, 1.11); | 508.00 ± 89.46/386.57 ± 69.60 | 493.71 ± 65.45/352.21 ± 66.79 | 0.5 (−0.04, 1.03); | None | N/A | N/A |
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