Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Table 2

Characteristics of studies included in this systematic review.

Author	Year	Sample; size	Mean age (year); (median/range)	% men	Chemotherapy	Radix Astragali intervention	Control
Cui et al. [5]	2009	40	60	57.5	FOLFOX	Single herb extract	No intervention
Feng [6]	2011	40		67.5	FOLFOX	Compound prescription	No intervention
Huang et al. [7]	2013	61	62.3	62.3	FOLFOX	Compound prescription	No intervention
Huang et al. [8]	2010	60	46	71.7	FOLFOX	Compound prescription	No intervention
Jin et al. [9]	2015	77	47.2	48.1	FOLFOX	Compound prescription	No intervention
Kong [10]	2012	40		52.5	OXAL	Compound prescription	No intervention
Li et al. [11]	2013	60	50.1	31.7	FOLFOX	Compound prescription	GSH
Liang et al. [12]	2012	84		70.2	FOLFOX	Compound prescription	No intervention
Liang et al. [13]	2015	135	47.8	67.4	FOLFOX	Compound prescription	No intervention
Lin and Luo [14]	2011	90	51	54.4	FOLFOX	Compound prescription	No intervention
Liu   et al. [15]	2011	60	61.5	64.3	FOLFOX, OXAL	Compound prescription	Mecobalamin
Liu [16]	2009	68		60.3	FOLFOX	Compound prescription	No intervention
Lv [17]	2015	90	53.0	53.3	OXAL	Compound prescription	Mecobalamin
Qin and Sun [18]	2015	42	55	61.9	FOLFOX	Compound prescription	Mecobalamin
Qin et al. [19]	2012	68	57.2	47.1	OXAL, TAX	Compound prescription	Cobamamide
Shen et al. [20]	2015	60	59.7	65.0	OXAL	Compound prescription	Mecobalamin
Sun et al. [21]	2010	60	55.3	63.3	FOLFOX, XELOX, TAX + 5-Fu	Compound prescription	Mecobalamin
Tan and Qi [22]	2015	63		60.3	OXAL	Compound prescription	Mecobalamin
Wang [23]	2015	60	52.3	50.0	FOLFOX	Compound prescription	Ca/Mg infusions
Wu et al. [24]	2015	89	49.2	70.8	Platinum, TAX,	Compound prescription	No intervention
Wu et al. [25]	2012	60		65.8	FOLFOX	Compound prescription	No intervention
Wu et al. [26]	2015	60	59.7	65.6	Platinum, TAX, VCR	Compound prescription	No intervention
Xu et al. [27]	2011	40		45.0	OXAL	Compound prescription	No intervention
Zhang and Lu [28]	2013	70	31–77	65.7	FOLFOX	Single herb extract +; thioctic acid	No intervention

FOLFOX: oxaliplatin + 5-fluorouracil + calcium folinate.
5-Fu: 5-fluorouracil.
GSH: glutathione.
OXAL: oxaliplatin.
TAX: taxol.
VCR: vincristine.
XELOX: oxaliplatin + capecitabine.