Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

Figure 2

Effect of baicalin on pulmonary arteriole remodeling in rats subjected to chronic hypoxia. (a, b) The WA/TA and WT/R ratios were significantly increased in rats subjected to continuous hypoxia, but baicalin attenuated this trend. (/group) indicates compared to the control group and indicates compared to the hypoxia group. (c) The nuclei density significantly decreased under continuous hypoxia, and the trend was partially attenuated by baicalin. (/group) indicates compared to the control group and indicates compared to the hypoxia group. (d) Baicalin inhibited hypoxic pulmonary arteriole remodeling, as indicated by HE staining.

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