Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

Figure 4

Expression of p-p38 in pulmonary arterioles and lung tissue. (a, b) p-p38 was expressed more abundantly in pulmonary arteriole cell nuclei in the hypoxia group than in the baicalin group and the control group, as visualized by immunohistochemistry. (/group) indicates compared to the control group and indicates compared to the hypoxia group. (c, d) Western blot analysis of p-p38 expression in the lung showed that p-p38 expression was higher in the hypoxia group than in the control group and that this increased expression was attenuated by baicalin treatment. Representative blots are shown. (/group) indicates compared to the control group and indicates compared to the hypoxia group.

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