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Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 2565169, 9 pages
http://dx.doi.org/10.1155/2016/2565169
Research Article

Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial

1Emergency Department, Peking Union Medical College Hospital, Beijing 100730, China
2Emergency Department, Beijing Hospital of the Ministry of Health, Beijing 100005, China
3Emergency Department, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
4Emergency Department, Zhongda Hospital, Dongnan University, Nanjing 210009, China
5Emergency Department, Hubei Provincial Hospital, Wuhan 430000, China
6Emergency Department, The First Affiliated Hospital of Huaxi Medical College of Sichuan University, Chengdu 610044, China
7Emergency Department, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200093, China
8Emergency Department, Saint Louis University, Saint Louis, MO 63130, USA
9Emergency Department, The First Affiliated Hospital of Kunming Medical University, Kunming 650034, China
10Emergency Department, PLA 263 Hospital, Beijing 101199, China

Received 4 February 2016; Revised 13 May 2016; Accepted 7 June 2016

Academic Editor: Kenji Watanabe

Copyright © 2016 Yi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. C. Angus and T. van der Poll, “Severe sepsis and septic shock,” The New England Journal of Medicine, vol. 369, no. 9, pp. 840–851, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. K.-M. Kaukonen, M. Bailey, S. Suzuki, D. Pilcher, and R. Bellomo, “Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012,” The Journal of the American Medical Association, vol. 311, no. 13, pp. 1308–1316, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. R. P. Dellinger, M. M. Levy, A. Rhodes et al., “Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012,” Critical Care Medicine, vol. 41, no. 2, pp. 580–637, 2013. View at Publisher · View at Google Scholar
  4. P. U. Unschuld, “The past 1000 years of Chinese medicine,” The Lancet, vol. 354, no. 6, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-L. Tang, B.-Y. Liu, and K.-W. Ma, “Traditional Chinese medicine,” The Lancet, vol. 372, no. 9654, pp. 1938–1940, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Scheid, “The globalisation of Chinese medicine,” Lancet, vol. 354, no. 10, supplement, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Gao, J. Leng, C.-M. Fu et al., “Interpretation of contemporary positioning of traditional Chinese medicine injections and analysis of key problems,” Zhongguo Zhong Yao Za Zhi, vol. 39, no. 17, pp. 3416–3419, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Dong and B. Shen, “Clinical effect of Shenfu injection in the sepsis bundle treatment of septic shock,” Journal of Emergency in Traditional Chinese Medicine, vol. 23, pp. 944–945, 2014. View at Google Scholar
  9. Y. Song, N. Zhang, Y. Jiang et al., “Simultaneous determination of aconite alkaloids and ginsenosides using online solid phase extraction hyphenated with polarity switching ultra-high performance liquid chromatography coupled with tandem mass spectrometry,” RSC Advances, vol. 5, no. 9, pp. 6419–6428, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. He, Q. Q. Wang, and X. Wu, “Effect of early used high dose Shenfu injection for the treatment of septic shock,” Journal of Emergency in Traditional Chinese Medicine, vol. 22, pp. 99–100, 2013. View at Google Scholar
  11. Z. Mou, Z. Lv, Y. Li, M. Wang, Q. Xu, and X. Yu, “Clinical effect of shenfu injection in patients with septic shock: a meta-analysis and systematic review,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 863149, 10 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. R. P. Dellinger, M. M. Levy, J. M. Carlet et al., “Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008,” Critical Care Medicine, vol. 36, no. 1, pp. 296–327, 2008. View at Google Scholar
  13. J. Bakker, P. Gris, M. Coffernils, R. J. Kahn, and J.-L. Vincent, “Serial blood lactate levels can predict the development of multiple organ failure following septic shock,” American Journal of Surgery, vol. 171, no. 2, pp. 221–226, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. P. W. Stacpoole, E. C. Wright, T. G. Baumgartner et al., “Natural history and course of acquired lactic acidosis in adults. DCA-Lactic Acidosis Study Group,” The American Journal of Medicine, vol. 97, no. 1, pp. 47–54, 1994. View at Publisher · View at Google Scholar · View at Scopus
  15. S. M. Forsythe and G. A. Schmidt, “Sodium bicarbonate for the treatment of lactic acidosis,” Chest, vol. 117, no. 1, pp. 260–267, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Varon and J. Varon, “Shenfu, traditional Chinese medicine in sepsis: are we ready for it?” American Journal of Emergency Medicine, vol. 33, no. 9, pp. 1244–1245, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. M. M. Levy, R. P. Dellinger, S. R. Townsend et al., “The surviving sepsis campaign: results of an international guideline-based performance improvement program targeting severe sepsis,” Critical Care Medicine, vol. 38, no. 2, pp. 367–374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Casserly, G. S. Phillips, C. Schorr et al., “Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database,” Critical Care Medicine, vol. 43, no. 3, pp. 567–573, 2015. View at Google Scholar
  19. Y. Tang, J. Choi, D. Kim et al., “Clinical predictors of adverse outcome in severe sepsis patients with lactate 2–4 mM admitted to the hospital,” Quarterly Journal of Medicine, vol. 108, no. 4, Article ID hcu186, pp. 279–287, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. A. E. Jones, N. I. Shapiro, S. Trzeciak, R. C. Arnold, H. A. Claremont, and J. A. Kline, “Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial,” Journal of the American Medical Association, vol. 303, no. 8, pp. 739–746, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. H. B. Nguyen, E. P. Rivers, B. P. Knoblich et al., “Early lactate clearance is associated with improved outcome in severe sepsis and septic shock,” Critical Care Medicine, vol. 32, no. 8, pp. 1637–1642, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Lv, D. Zhuo, S. W. Xiong, L. Min, and S. Qiao, “Effect of Shenfu injection on oxygen metabolism in patients with septic shock,” Journal of Jiangxi University of Traditional Chinese Medicine, vol. 25, pp. 30–32, 2013. View at Google Scholar
  23. Y. Xu, B. H. Chen, L. Zhong, and H. Wu, “Study of integrated therapy in the early recovery of septic shock,” Soft Science of Health, vol. 26, pp. 578–580, 2013. View at Google Scholar
  24. W. Zhang, B. Wu, and J. Guan, “Research on septic shock treated with injection of Shenfu,” Medical Information, vol. 9, pp. 4903–4904, 2011. View at Google Scholar
  25. H. Lin, C. Ma, R. Wang, and D. Liang, “Effect of Shenfu injection on blood lactate and prognosis in patients with severe pneumonia,” Journal of Emergency in Traditional Chinese Medicine, vol. 2, p. 11, 2013. View at Google Scholar
  26. S. Sun, X. Mo, and C. Ma, “Shenfu injection early intervention on the organ function with septic shock,” Journal of Emergency in Traditional Chinese Medicine, vol. 17, pp. 1392–1393, 2008. View at Google Scholar
  27. M.-Q. Li, C.-G. Pan, X.-M. Wang et al., “Effect of the shenfu injection combined with early goal-directed therapy on organ functions and outcomes of septic shock patients,” Cell Biochemistry and Biophysics, vol. 72, no. 3, pp. 807–812, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. W. Gu, C. Li, W. Yin, Z. Guo, X. Hou, and D. Zhang, “Shen-Fu injection reduces postresuscitation myocardial dysfunction in a porcine model of cardiac arrest by modulating apoptosis,” Shock, vol. 38, no. 3, pp. 301–306, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. X.-F. Ji, H.-B. Ji, D.-Y. Sang, S. Wang, L. Yang, and C.-S. Li, “Shen-Fu injection reduces impaired myocardial β-adrenergic receptor signaling after cardiopulmonary resuscitation,” Chinese Medical Journal, vol. 126, no. 4, pp. 697–702, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. M.-Y. Zhang, X.-F. Ji, S. Wang, and C.-S. Li, “Shen-Fu injection attenuates postresuscitation lung injury in a porcine model of cardiac arrest,” Resuscitation, vol. 83, no. 9, pp. 1152–1158, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Gu, C. Li, W. Yin, X. Hou, and D. Zhang, “Effects of Shen-Fu injection on the expression of T-cell-specific transcription factors T-bet/gata-3 in porcine postresuscitation lung injury,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 464650, 8 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Hou, C. Li, W. Gu, Z. Guo, W. Yin, and D. Zhang, “Effect of Shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine,” American Journal of Emergency Medicine, vol. 31, no. 8, pp. 1159–1164, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. Q. Zhang, C.-S. Li, S. Wang, and W. Gu, “Effects of Chinese Medicine Shen-Fu Injection (参附注射液) on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in a porcine model,” Chinese Journal of Integrative Medicine, vol. 22, no. 2, pp. 101–109, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. L.-J. Yang, J. Wang, Z.-F. Tian, and Y.-F. Yuan, “Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat,” Neurological Sciences, vol. 34, no. 9, pp. 1571–1574, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. W. Gu, X. Hou, H. Zhou, and C. Li, “Protective effect of Shen-Fu injection on neuronal mitochondrial function in a porcine model of prolonged cardiac arrest,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 523847, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus