A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

Table 1

Relationship between modern pharmacology and traditional efficacies of XYP.

Active compounds	Modern pharmacology of traditional efficacies
	Dispersing stagnated liver Qi for relieving Qi stagnation	Nourishing the blood and invigorating the spleen
Saikosaponin	Increasing IL-2 and IgM level [15], reducing LPO [16]	Keeping a balance of TH/TS [15]
Ferulic acid	Decreasing LPO and MAD, balancing TXA2/PGI2, reducing blood viscosity [17]	Increasing SOD activity, enhancing hematopoietic function, keeping the balance of TXB2/6-keto-PGF1α [17]
Ligustilide	Decreasing MAD, balancing TXA2/PGI2, reducing blood viscosity [18, 19]	Increasing activity of SOD and GSH-PX [18, 19]
TGP	Decreasing MAD, reducing blood viscosity, balancing TXA2/PGI2, increasing IL-2 [19, 20]	Keeping a balance of TH/TS, increasing activity of SOD and GSH-PX, enhancing hematopoietic function, improving the quality of erythrocytes [19, 20]
Atractylenolide I	—	Strengthening digestion and absorption, enhancing salivary amylase activity, slowing the heart rate [21]
Atractylenolide III	—	Strengthening digestion and absorption [21]
Pachyman	Scavenging free radical, reducing LPO and MAD, lowering blood sugar [22]	Increasing SOD activity [22]
Pachymic	—	—
Glycyrrhizin	Reducing MAD, increasing IL-1β, IL-6, IL-10, scavenging free radical [23]	Increasing SOD activity, increasing the plasma TP [23]