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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3106980, 8 pages
http://dx.doi.org/10.1155/2016/3106980
Research Article

Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models

Department of Biochemistry, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China

Received 21 August 2015; Revised 14 January 2016; Accepted 17 January 2016

Academic Editor: Caigan Du

Copyright © 2016 Hu Haiyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Hardy and D. J. Selkoe, “The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics,” Science, vol. 297, no. 5580, pp. 353–356, 2002, Erratum in: Science, vol. 297, no. 5590, p. 2209, 2002. View at Publisher · View at Google Scholar
  2. J. J. Rodríguez, V. C. Jones, M. Tabuchi et al., “Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's Ddisease,” PLoS ONE, vol. 3, no. 8, Article ID e2935, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. H. G. Kuhn, H. Dickinson-Anson, and F. H. Gage, “Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation,” The Journal of Neuroscience, vol. 16, no. 6, pp. 2027–2033, 1996. View at Google Scholar · View at Scopus
  4. K. Jin, A. L. Peel, X. O. Mao et al., “Increased hippocampal neurogenesis in Alzheimer's disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 1, pp. 343–347, 2004. View at Publisher · View at Google Scholar
  5. K. Boekhoorn, M. Joels, and P. J. Lucassen, “Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus,” Neurobiology of Disease, vol. 24, no. 1, pp. 1–14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. L. Ren and P. P. Zuo, “Neural regeneration: role of traditional Chinese medicine in neurological diseases treatment,” Journal of Pharmacological Sciences, vol. 120, no. 3, pp. 139–145, 2012. View at Publisher · View at Google Scholar
  7. Y.-C. Si, Q. Li, C.-E. Xie, X. Niu, X.-H. Xia, and C.-Y. Yu, “Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells,” Chinese Medicine, vol. 9, no. 1, article 13, 2014. View at Publisher · View at Google Scholar
  8. W.-J. Zhang, P. Hufnagl, B. R. Binder, and J. Wojta, “Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-κB activation and adhesion molecule expression,” Thrombosis and Haemostasis, vol. 90, no. 5, pp. 904–914, 2003. View at Google Scholar · View at Scopus
  9. L.-H. Qiu, X.-J. Xie, and B.-Q. Zhang, “Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation,” Biological and Pharmaceutical Bulletin, vol. 33, no. 4, pp. 641–646, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. S.-B. Wang, J.-F. Qiu, Q.-H. Bai et al., “A study on protection of astragaioside IV about oxidative stress on PC12 cells induced by H2O2,” Chinese Pharmacological Bulletin, vol. 27, no. 11, pp. 1603–1609, 2011 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  11. Y. He, M. Du, Y. Gao et al., “Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels,” PLoS ONE, vol. 8, no. 10, Article ID e76495, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Luo, Z. Qin, Z. Hong et al., “Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia,” Neuroscience Letters, vol. 363, no. 3, pp. 218–223, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. C.-Y. Cheng, C.-H. Yao, B.-S. Liu, C.-J. Liu, G.-W. Chen, and Y.-S. Chen, “The role of astragaloside in regeneration of the peripheral nerve system,” Journal of Biomedical Materials Research Part A, vol. 76, no. 3, pp. 463–469, 2006. View at Publisher · View at Google Scholar
  14. J. Zhong, H. Cao, Z. Chen, F. Zhou, and X. Tan, “Wnt signaling pathways participate in Astragalus injection-induced differentiation of bone marrow mesenchymal stem cells,” Neuroscience Letters, vol. 553, pp. 29–34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Miltiadous, G. Kouroupi, A. Stamatakis, P. N. Koutsoudaki, R. Matsas, and F. Stylianopoulou, “Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration,” Stem Cells Translational Medicine, vol. 2, no. 3, pp. 185–198, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Iqbal, S. F. Kazim, S. Bolognin, and J. Blanchard, “Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer’s disease and related neurodegenerative conditions,” Neural Regeneration Research, vol. 9, no. 16, pp. 1518–1519, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Park, H. J. Lee, S. S. Joo et al., “Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction,” Experimental Neurology, vol. 234, no. 2, pp. 521–526, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Yu and G. A. Silva, “Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders,” Neurosurgical Focus, vol. 24, no. 3-4, p. E11, 2008. View at Publisher · View at Google Scholar
  19. S. Hitoshi, T. Alexson, V. Tropepe et al., “Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells,” Genes and Development, vol. 16, no. 7, pp. 846–858, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. J. P. Magnusson, C. Göritz, J. Tatarishvili et al., “A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse,” Science, vol. 346, no. 6206, pp. 237–241, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Tanveer, A. Gowran, J. Noonan, S. E. Keating, A. G. Bowie, and V. A. Campbell, “The endocannabinoid, anandamide, augments notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats,” The Journal of Biological Chemistry, vol. 287, no. 41, pp. 34709–34721, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. G. van Tetering and M. Vooijs, “Proteolytic cleavage of Notch: ‘HIT and RUN’,” Current Molecular Medicine, vol. 11, no. 4, pp. 255–269, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Hai-yan, J. Guo-qin, Z. Xue-li et al., “Effects of Astragaloside Ⅳ on the proliferation and differentiation in neural stem cells of Aβ140 injured embryo mouse,” China Journal of Traditional Chinese Medicine and Pharmacy, vol. 29, no. 1, pp. 246–248, 2014 (Chinese). View at Google Scholar
  24. N. Chen, Q. Zhang, Y. Du, G.-G. Chen, and L.-L. Zhu, “Pharmacokinetics and tissue distribution of astragaloside IV in rats,” Chinese Journal of Bioprocess Engineering, vol. 4, no. 3, pp. 67–72, 2006 (Chinese). View at Google Scholar
  25. B. A. Reynolds and S. Weiss, “Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system,” Science, vol. 255, no. 5052, pp. 1707–1710, 1992. View at Publisher · View at Google Scholar · View at Scopus